Plasmonic Metasurfaces Based on Nanopin-Cavity Resonator for Quantitative Colorimetric Ricin Sensing
Plasmonic Metasurfaces Based on Nanopin-Cavity Resonator for Quantitative Colorimetric Ricin Sensing
复制标题
基于纳米针腔谐振器的等离激元超表面用于定量比色蓖麻毒素传感
DOI：
10.1002/smll.201601710
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发表时间：
2017-01-04
期刊：
影响因子：
13.3
通讯作者：
Huang, Yun
中科院分区：
文献类型：
--
作者：
Fan, Jiao-Rong;Zhu, Jia;Huang, Yun
鉴于生物武器威胁的潜在毒性，蓖麻毒素的快速视觉识别和感测已经引起了相当大的兴趣，同时迄今为止仍然是一项具有挑战性的任务。在这项研究中，金纳米针为基础的比色传感器实现了蓖麻毒素的定性识别和分析的一个可调的变化。结果表明，这种基于纳米针腔谐振器的等离子体超颖表面表现出反射色的外观，由于在可见光区的窄带宽的驻波共振的激发。这种清晰的颜色变化是由不同的共振波长定义的反射颜色混合的结果。此外，有色超颖表面在窄的折射率范围内呈现尖锐的色差，这使得它们特别适合于传感应用。因此，这种抗体功能化的纳米针腔生物传感器具有高灵敏度和快速响应的特点，允许在10-120 ng mL（-1）范围内进行可视化定量蓖麻毒素检测（0.15 x 10（-9）-1.8 x 10（-9）m），检测限为10 ng mL（-1），并且典型的测量时间小于10分钟。可以设想将这种纳米针超颖表面在芯片上集成到便携式比色微流体装置，用于各种生化分子的定量研究。
In view of the toxic potential of a bioweapon threat, rapid visual recognition and sensing of ricin has been of considerable interest while remaining a challenging task up to date. In this study, a gold nanopin-based colorimetric sensor is developed realizing a multicolor variation for ricin qualitative recognition and analysis. It is revealed that such plasmonic metasurfaces based on nanopin-cavity resonator exhibit reflective color appearance, due to the excitation of standing-wave resonances of narrow bandwidth in visible region. This clear color variation is a consequence of the reflective color mixing defined by different resonant wavelengths. In addition, the colored metasurfaces appear sharp color difference in a narrow refractive index range, which makes them especially well-suited for sensing applications. Therefore, this antibody-functionalized nanopin-cavity biosensor features high sensitivity and fast response, allowing for visual quantitative ricin detection within the range of 10-120 ng mL(-1) (0.15 x 10(-9)-1.8 x 10(-9) m), a limit of detection of 10 ng mL(-1), and the typical measurement time of less than 10 min. The on-chip integration of such nanopin metasurfaces to portable colorimetric microfluidic device may be envisaged for the quantitative studies of a variety of biochemical molecules.