Modulation of host immune defenses by Aeromonas and Yersinia species: convergence on toxins secreted by various secretion systems.
Modulation of host immune defenses by Aeromonas and Yersinia species: convergence on toxins secreted by various secretion systems.
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DOI：
10.3389/fcimb.2013.00070
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发表时间：
2013
影响因子：
5.7
通讯作者：
Chopra AK
中科院分区：
文献类型：
--
作者：
Rosenzweig JA;Chopra AK
与其他病原菌一样，耶尔森氏菌和气单胞菌一直在与各自的宿主共同进化。虽然前者是一种真正的人类病原体，但后者作为一种新出现的致病因子已获得公证。为了应对免疫细胞的挑战，细菌病原体已经发展出多种机制，使它们能够存活，并且有时能够主导各种宿主免疫防御系统。细菌第三型分泌系统（T3 SS）在进化上来源于鞭毛亚基，并充当微生物可以直接将抗宿主因子/效应蛋白注射/易位到靶向宿主免疫细胞中的载体。大量的革兰氏阴性细菌病原体具有T3 SS，使它们能够破坏宿主细胞信号传导、肌动蛋白细胞骨架重排，甚至诱导宿主细胞凋亡和焦变性途径。所有致病性耶尔森氏菌和大多数气单胞菌属物种都具有T3 SS，但它们也具有T2和T6分泌的毒素/效应蛋白。这篇综述将集中在T3 SS效应子耶尔森氏菌外膜蛋白J（YopJ）和气单胞菌AexU蛋白，从大肠杆菌分离物SSU中分离出来，缓和宿主免疫系统防御的机制。此外，气单胞菌T2 SS分泌细胞毒性肠毒素Act和溶血素共调节蛋白（Hcp）与宿主细胞凋亡/焦亡相关的机制也已阐明。还将讨论T6 SS效应器。
Like other pathogenic bacteria, Yersinia and Aeromonas species have been continuously co-evolving with their respective hosts. Although the former is a bonafide human pathogen, the latter has gained notararity as an emerging disease-causing agent. In response to immune cell challenges, bacterial pathogens have developed diverse mechanism(s) enabling their survival, and, at times, dominance over various host immune defense systems. The bacterial type three secretion system (T3SS) is evolutionarily derived from flagellar subunits and serves as a vehicle by which microbes can directly inject/translocate anti-host factors/effector proteins into targeted host immune cells. A large number of Gram-negative bacterial pathogens possess a T3SS empowering them to disrupt host cell signaling, actin cytoskeleton re-arrangements, and even to induce host-cell apoptotic and pyroptotic pathways. All pathogenic yersiniae and most Aeromonas species possess a T3SS, but they also possess T2- and T6-secreted toxins/effector proteins. This review will focus on the mechanisms by which the T3SS effectors Yersinia outer membrane protein J (YopJ) and an Aeromonas hydrophila AexU protein, isolated from the diarrheal isolate SSU, mollify host immune system defenses. Additionally, the mechanisms that are associated with host cell apoptosis/pyroptosis by Aeromonas T2SS secreted Act, a cytotoxic enterotoxin, and Hemolysin co-regulated protein (Hcp), an A. hydrophila T6SS effector, will also be discussed.
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影响因子：
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