Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria.
Shared idiotypes among monoclonal antibodies specific for different immunodominant sugars of lipopolysaccharide of different Gram-negative bacteria.
复制标题
对不同革兰氏阴性菌脂多糖的不同免疫显性糖具有特异性的单克隆抗体之间共有的独特型。
DOI：
10.1073/pnas.79.5.1616
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发表时间：
1982
影响因子：
11.1
通讯作者：
Bona,CA
中科院分区：
文献类型：
--
作者：
Hiernaux,J;Bona,CA
革兰氏阴性菌脂多糖(LPS)中不同免疫优势糖的特异性单抗具有共同的独特型(ID)。第一组单抗是针对大肠杆菌0113LPS的，而第二组是针对变态沙门氏菌的。用针对大肠杆菌脂多糖结合单抗的单抗和针对骨髓瘤蛋白MOPC 384和MOPC 870的同基因抗384ID抗体对这两组单抗所携带的共同独特位进行鉴定。我们的数据表明，对于一个抗原家族的抗体来说，共享独特位是很常见的。
Shared idiotypes (Ids) were identified on monoclonal antibodies specific for different immunodominant sugars in the lipopolysaccharide (LPS) of Gram-negative bacteria. The first group of monoclonal antibodies is specific for Escherichia coli 0113 LPS, whereas the second group is specific for Salmonella tranaroa LPS. The shared idiotopes borne by these two groups of monoclonal antibodies were identified with monoclonal anti-Id antibodies specific for E. coli LPS-binding monoclonal antibodies and with syngeneic anti-384Id antibodies specific for MOPC 384 and MOPC 870 myeloma proteins. Our data suggest that shared idiotopes are common for antibodies for an antigenic family.