CHARACTERIZATION OF PEAK-E, A NOVEL AMINO-ACID ASSOCIATED WITH EOSINOPHILIA-MYALGIA-SYNDROME
CHARACTERIZATION OF PEAK-E, A NOVEL AMINO-ACID ASSOCIATED WITH EOSINOPHILIA-MYALGIA-SYNDROME
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DOI：
10.1126/science.2270484
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发表时间：
1990-12-21
期刊：
影响因子：
56.9
通讯作者：
GLEICH, GJ
中科院分区：
文献类型：
--
作者：
MAYENO, AN;LIN, F;GLEICH, GJ
流行病学研究将嗜酸性粒细胞增多-肌痛综合征（EMS）与摄入含有污染物的色氨酸（“E峰”）密切相关。先前的报道已经表明峰E是二色氨酸N α-乙醛的动物。光谱和化学研究现在证明峰E是1，1“-亚乙基双[色氨酸]。这种新型氨基酸可能是导致EMS的病原体，也可能是一种尚未鉴定的病原体的标记物。
Epidemiologic studies strongly associate eosinophilia-myalgia syndrome (EMS) with ingestion of tryptophan containing a contaminant ("peak E"). Prior reports have suggested that peak E is the di-tryptophan N.alpha.-animal of acetaldehyde. Spectral and chemical studies now demonstrate that peak E is 1,1''-ethylidenebis [tryptophan]. This novel amino acid my be the etiological agent responsible for EMS, or it may be a marker of a still unidentified causal agent.