Highly active and selective telechelic antimicrobial poly(2-oxazoline) copolymers
Highly active and selective telechelic antimicrobial poly(2-oxazoline) copolymers
复制标题
DOI：
10.1016/j.polymer.2017.04.074
复制
发表时间：
2017-06-02
期刊：
影响因子：
4.6
通讯作者：
Tiller, Joerg C.
中科院分区：
文献类型：
--
作者：
Krumm, Christian;Hijazi, Montasser;Tiller, Joerg C.
遥爪抗微生物聚合物的卫星基团效应（SG）允许增加或减少聚（2-甲基-2-恶唑啉）末端的杀生物十二烷基三甲基铵（DDA）基团的抗微生物活性。这类聚合物显示出良好的抗微生物活性，其对致病细菌金黄色葡萄球菌的MIC值低至10 μ g（-1），并且对血细胞具有中等的选择性（HC 50/MIC：10-120）。在这里，我们表明，这种大分子的聚合物主链的性质和结构的系统变化导致在杀生物聚合物中对金黄色葡萄球菌的最高抗微生物活性（MICs.aureus = 1-1.6 μ g ml（-1））和已知的两亲性抗微生物聚合物的最佳血细胞相容性（HC 50/MIC aureus = 1500-1700）。此外，聚合物显示出对革兰氏阳性细菌（MICE.coli./ MIC.aureus高达750），这是由于卫星基团效应与聚合物主链的优化的亲水/疏水平衡相结合。(C)2017爱思唯尔有限公司版权所有
The satellite group effect (SG) of telechelic antimicrobial polymers allows to increase or diminish the antimicrobial activity of the biocidal dodecyltrimethylammonium (DDA) group at the terminal of poly(2methyl-2-oxazoline). Such polymers show good antimicrobial activities with MIC values as low as 10 mu g(-1) against the pathogenic bacterium Staphylococcus aureus and moderate selectivity with respect to blood cells (HC50/MIC: 10-120). Here, we show that the systematic variation of the nature and structure of the polymer backbone of such macromolecules results in biocidal polymers that rank among the highest antimicrobial activity against Staphylococcus aureus (MICs.aureus = 1-1.6 mu g ml(-1)) and the best blood cell compatibilities (HC50/MICs aureus = 1500-1700) known for amphiphilic antimicrobial polymers. Further, the polymers show a very high selectivity for Gram-positive bacteria (MICE.coli./MICs.aureus up to 750), which is due to the satellite group effect in combination with optimized hydrophilic/hydrophobic balance of the polymer backbone. (C) 2017 Elsevier Ltd. All rights reserved.