Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: the PEACH trial
Feasibility and efficacy of a supervised exercise intervention in de-conditioned cancer survivors during the early survivorship phase: the PEACH trial
复制标题
DOI：
10.1007/s11764-013-0294-6
复制
发表时间：
2013-12-01
影响因子：
3.7
通讯作者：
Hussey, J.
中科院分区：
文献类型：
--
作者：
Broderick, J. M.;Guinan, E.;Hussey, J.
本研究旨在评估为期8周的有监督的有氧运动计划在化疗结束后2-6个月内的去条件癌症幸存者中的可行性和有效性。参与者被随机分配到为期8周，每周两次的有监督的有氧运动训练方案（n = 23）或常规护理组（n = 20）。可行性评估招募率，计划坚持和参与者的反馈。主要结果是在基线（0周）、干预后（8周）和3个月随访时通过改良布鲁斯体能测试评估的有氧体能。次要结果包括体力活动、腰围、疲劳和生活质量。招募率为81%，坚持监督锻炼的比例为78. 3%。在8周[平均3.0 mL kg（-1）min（-1）（95% CI -1.1-7.0）]和3个月随访[2.1 mL kg（-1）min（-1）（-2.3-6.6）]时，发现运动组和常规护理组之间的有氧适应性存在有意义的差异，尽管这些差异没有达到统计学显著性（p值> 0.14）。在8周（p = 0.01）和3个月随访（p = 0.03）时，与常规护理组相比，运动组（EG）自我报告的身体活动增加，在8周（p = 0.03）和3个月随访（p = 0.04）时，发现有利于EG的身体健康的显著差异。改善疲劳（p = 0.01），总生活质量加疲劳（p = 0.04），以及复合身体功能评分PEACH试验表明，8周的监督有氧运动训练是可行的，可以改善有氧健身，在早期生存期内开始的运动干预似乎是安全、可行的，并可能导致生活质量和疲劳的改善。
This study aims to evaluate the feasibility and efficacy of an 8-week supervised exercise program in de-conditioned cancer survivors within 2-6 months of chemotherapy completion.Participants were randomly assigned to an 8-week, twice-weekly, supervised aerobic exercise training regime (n = 23) or a usual care group (n = 20). Feasibility was assessed by recruitment rate, program adherence and participant feedback. The primary outcome was aerobic fitness assessed by the Modified Bruce fitness test at baseline (0 weeks), post-intervention (8 weeks) and at 3-month follow-up. Secondary outcomes included physical activity, waist circumference, fatigue and quality of life.The recruitment rate was 81 % and adherence to the supervised exercise was 78.3 %. Meaningful differences in aerobic fitness between the exercise and usual care groups at both the 8-week [mean 3.0 mL kg(-1) min(-1) (95 % CI -1.1-7.0)] and 3-month follow-up [2.1 mL kg(-1) min(-1) (-2.3-6.6)] were found, although these differences did not achieve statistical significance (p values > 0.14). Self-reported physical activity increased in the exercise group (EG) compared to the usual care group at both 8-week (p = 0.01) and 3-month follow-up (p = 0.03) and significant differences in favour of the EG were found for physical well-being at both the 8-week (p = 0.03) and 3-month follow-up (p = 0.04). Improvements in fatigue (p = 0.01), total quality of life plus fatigue (p = 0.04), and a composite physical functioning score (p = 0.01) at the 3-month follow-up were also found.The PEACH trial suggests that 8 weeks of supervised aerobic exercise training was feasible and may improve aerobic fitness, fatigue and quality of life in de-conditioned cancer survivors during the early survivorship phase.Exercise interventions commenced in the early survivorship phase appear safe, feasible and may lead to improvements in QOL and fatigue.