Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients
Association of HLA-DRB1*16 with chronic discoid lupus erythematosus in Mexican mestizo patients
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DOI：
10.1111/j.1365-2230.2007.02391.x
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发表时间：
2007-07-01
影响因子：
4.1
通讯作者：
Granados, J.
中科院分区：
文献类型：
--
作者：
Lopez-Tello, A.;Rodriguez-Carreon, A. A.;Granados, J.
背景慢性盘状红斑狼疮（CDLE）存在于15-30%的系统性红斑狼疮（SLE）患者中。大约5%的CDLE病例在疾病的某个阶段可演变为SLE。本研究的目的是确定墨西哥混血儿CDLE患者的HLA-DRB 1等位基因的基因频率，无论是否存在全身性疾病。该研究包括28名患有CDLE的墨西哥混血患者，他们参加了墨西哥城的逾越节皮肤病中心。采用PCR扩增DNA后进行序列特异性寡核苷酸分型，进行HLA-DRB 1和DQ等位基因分型。该研究还包括99名种族匹配的健康个体作为对照。在患者组中，HLA-DR 4（P = 0.016，OR = 2.24，95%CI 1.14-4.38）和HLA-DR 16（P = 0.005，OR = 5.51，95%CI 1.49-21.08）等位基因频率显著增高。HLA-DRB 1等位基因似乎参与了墨西哥混血人群中CDLE的遗传易感性。
Background. Chronic discoid lupus erythematosus (CDLE) is present in 15-30% of patients with systemic lupus erythematosus ( SLE). Approximately 5% of CDLE cases can evolve to SLE at some stage of the disease.Aim. The aim of this study was to determine gene frequencies of HLA-DRB1 alleles in Mexican mestizo patients with CDLE, irrespective of the presence of systemic disease.Methods. The study comprised 28 Mexican mestizo patients with CDLE who were attending the Passover Dermatology Centre, in Mexico City. HLA-DRB1 and DQ allele typing was performed by sequence-specific oligotyping after DNA amplification using PCR. The study also included 99 ethnically matched healthy individuals as controls.Results. In the patient group, a significantly increased gene frequency was found for the HLA-DR4 ( P = 0.016, OR = 2.24, 95% CI 1.14-4.38) and HLA-DR16 alleles ( P = 0.005, OR = 5.51, 95% CI 1.49-21.08).Conclusion. HLA-DRB1 alleles seem to be involved in the genetic susceptibility to CDLE in the Mexican mestizo population.