THE GENE FOR FAMILIAL POLYPOSIS-COLI MAPS TO THE LONG ARM OF CHROMOSOME-5
THE GENE FOR FAMILIAL POLYPOSIS-COLI MAPS TO THE LONG ARM OF CHROMOSOME-5
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DOI：
10.1126/science.3479843
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发表时间：
1987-12-04
期刊：
影响因子：
56.9
通讯作者：
WHITE, R
中科院分区：
文献类型：
--
作者：
LEPPERT, M;DOBBS, M;WHITE, R
腺瘤性息肉病的遗传缺陷局限于5号染色体长臂上的一个小区域。利用16个标记位点构建了该染色体的连锁图。当5个分离腺瘤性结肠息肉病基因的激酶被鉴定为具有多个标记时，在一个标记和疾病基因之间发现了显著的连锁。连锁分析确定了5号染色体的原始遗传图谱中缺陷基因的位置。
The inherited genetic defect in adenomatous polyposis has been localized to a small region on the long arm of chromosome 5. Sixteen DNA marker loci were used to construct a linkage map of the chromosome. When five kindreds segregating a gene for adenomatous polyposis coli were characterized with a number of the markers, significant linkage was found between one marker and the disease gene. Linkage analysis determined the location of the defective gene within a primary genetic map of chromosome 5.