Iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids.
Iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids.
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DOI：
10.1039/c9cc09984k
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发表时间：
2020-02
影响因子：
4.9
通讯作者：
Linwei Zeng;Ren-Hong Chen;Chen Zhang;Hujun Xie;Sunliang Cui
中科院分区：
文献类型：
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作者：
Linwei Zeng;Ren-Hong Chen;Chen Zhang;Hujun Xie;Sunliang Cui
描述了2-炔基酚和羧酸的铱（I）催化的水合/酯化。各种2-炔基酚和羧酸可用于该方法中，通过区域和立体选择性加成反应，然后分子内重排，得到芳族邻酰氧基酮。该方法具有反应条件温和、底物范围广等特点。进行进一步的转化以证明合成应用。
An iridium(i)-catalyzed hydration/esterification of 2-alkynylphenols and carboxylic acids is described. Various 2-alkynylphenols and carboxylic acids could be used in this process to furnish aromatic ortho-acyloxyketones via a regio- and stereo-selective addition reaction followed by intramolecular rearrangement. This protocol features mild reaction conditions and broad substrate scope. Further transformations were conducted to demonstrate the synthetic application.