Regulation of contractile ring formation and septation in Schizosaccharomyces pombe.
Regulation of contractile ring formation and septation in Schizosaccharomyces pombe.
复制标题
DOI：
10.1016/j.mib.2015.08.001
复制
发表时间：
2015-12
影响因子：
5.4
通讯作者：
Gould KL
中科院分区：
文献类型：
--
作者：
Willet AH;McDonald NA;Gould KL
在 20 世纪 80 年代和 90 年代开创性的基因筛选的推动下，裂殖酵母粟酒裂殖酵母 (Schizosaccharomyces pombe) 已成为胞质分裂研究的强大模型生物。粟酒裂殖酵母细胞呈杆状，与哺乳动物细胞类似，利用位于内侧的基于肌动蛋白和肌球蛋白的收缩环进行分裂。细胞壁分裂隔膜沉积在收缩环后面，形成每个子细胞的新末端。在这里，我们讨论了我们对通过福尔明蛋白调节收缩环形成以及分裂隔膜在粟酒裂殖酵母细胞分裂中的作用的理解的最新进展。
The fission yeast Schizosaccharomyces pombe has become a powerful model organism for cytokinesis studies, propelled by pioneering genetic screens in the 1980s and 1990s. S. pombe cells are rod-shaped and divide similarly to mammalian cells, utilizing a medially-placed actin- and myosin-based contractile ring. A cell wall division septum is deposited behind the constricting ring, forming the new ends of each daughter cell. Here we discuss recent advances in our understanding of the regulation of contractile ring formation through formin proteins and the role of the division septum in S. pombe cell division.