A new class of silica cross-linked micellar core-shell nanoparticles
A new class of silica cross-linked micellar core-shell nanoparticles
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DOI：
10.1021/ja060367p
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发表时间：
2006-05-17
影响因子：
15
通讯作者：
Fang, Erica
中科院分区：
文献类型：
--
作者：
Huo, Qisheng;Liu, Jun;Fang, Erica
由表面活性剂和聚合物组成的胶束纳米粒子在药物控释、分子成像和传感等领域引起了材料和生物医学界的广泛关注，但其长期稳定性仍然是一个热门的研究课题。在这里，我们报告了一类新的坚固的，超细的二氧化硅核壳纳米颗粒，由二氧化硅交联，单个嵌段共聚胶束形成。与纯聚合物胶束相比，新型核壳纳米粒子的主要优点是稳定性显著提高，并且在稀释过程中不会分解。我们还研究了二氧化硅交联胶束粒子的载药和释药性能，发现新的核壳纳米粒子具有较慢的释放速度，使得被包裹的分子在相同的实验条件下可以在更长的时间内缓慢释放。通过与二氧化硅基质共缩合，可以很容易地结合一系列官能团。已经证明了将疏水剂输送到癌细胞中的可能性。由于其独特的结构和性质，这些新型的核壳纳米粒子可能为成像、检测和治疗提供新的纳米医学平台，以及新型胶体粒子和多功能材料的构建块。
Micellar nanoparticles made of surfactants and polymers have attracted wide attention in the materials and biomedical community for controlled drug delivery, molecular imaging, and sensing; however, their long-term stability remains a topic of intense study. Here we report a new class of robust, ultrafine silica core-shell nanoparticles formed from silica cross-linked, individual block copolymer micelles. Compared with pure polymeric micelles, the main advantage of the new core-shell nanoparticles is that they have significantly improved stability and do not break down during dilution. We also studied the drug loading and release properties of the silica cross-linked micellar particles, and we found that the new core-shell nanoparticles have a slower release rate which allows the entrapped molecules to be slowly released over a much longer period of time under the same experimental conditions. A range of functional groups can be easily incorporated through co-condensation with the silica matrix. The potential to deliver hydrophobic agents into cancer cells has been demonstrated. Because of their unique structures and properties, these novel core-shell nanoparticles could potentially provide a new nanomedicine platform for imaging, detection, and treatment, as well as novel colloidal particles and building blocks for mutlifunctional materials.