The significant association of CCND1 genotypes with colorectal cancer in Taiwan
The significant association of CCND1 genotypes with colorectal cancer in Taiwan
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DOI：
10.1007/s13277-015-3347-9
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发表时间：
2015-08-01
期刊：
影响因子：
--
通讯作者：
Bau, Da-Tian
中科院分区：
文献类型：
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作者：
Huang, Chung-Yu;Tsai, Chia-Wen;Bau, Da-Tian
结直肠癌是世界上最常见的恶性肿瘤之一，其发病率约有20%是由低外显性易感基因引起的，每年全球确诊病例达100万例。细胞周期蛋白D_1(CCND_1)调控细胞周期转换可能决定了基因组不稳定和致癌的易感个体。本研究旨在探讨台湾地区CCND1基因型别对结直肠癌风险的贡献。对362例结直肠癌患者和362例年龄、性别匹配的正常对照进行CCND1A870G(Rs9344)和G1722C(Rs678653)基因分型。CCND1A870G的基因频率(P=9.71×10~(-4))和等位基因频率(P=0.0017)在结直肠癌组和对照组之间差异有统计学意义。此外，携带AG或GG基因的个体患结直肠癌的优势比比AA基因高0.56倍或0.51倍(95%可信区间分别为0.40-0.78和0.32-0.81)。此外，CCND1A870G的G等位基因对非吸烟者和非饮酒者的结直肠癌风险有保护作用(P分别为0.0012和0.0007)。这些结果支持细胞周期调控可能在结直肠癌的发生发展中起作用的观点，CCND1A870G基因分型可能是结直肠癌早期检测的一种可行技术。
Colorectal cancer, one million cases of diagnosis worldwide annually, is one of the most common malignant tumors and 20 % incidence caused by low penetrance susceptibility genes. Cyclin D1 (CCND1) regulating cell cycle transition may determine the susceptible individuals to genomic instability and carcinogenesis. The study aimed at examining the contribution of CCND1 genotypes to colorectal cancer risk in Taiwan. The genotypes of CCND1 A870G (rs9344) and G1722C (rs678653) were determined among 362 colorectal cancer patients and 362 age- and gender-matched cancer-free controls. Significant differences were observed between colorectal cancer and control groups in the distributions of genotypic (P = 9.71 x 10(-4)) and allelic (P = 0.0017) frequencies at CCND1 A870G. Additionally, individuals carried AG or GG genotype had 0.56- or 0.51-fold higher of odds ratios for developing colorectal cancer than the AA genotype (95 % confidence intervals = 0.40-0.78 and 0.32-0.81, respectively). Furthermore, G allele of CCND1 A870G performed a protective effects for nonsmokers and nonalcohol drinkers (P = 0.0012 and 0.0007, respectively) on colorectal cancer risk. These findings support the concept that the cell cycle regulation may play a role in colorectal cancer initiation and development and CCND1 A870G genotyping maybe a feasible technology for colorectal cancer early detection.