Structural organization of the mormyrid electrosensory lateral line lobe
Structural organization of the mormyrid electrosensory lateral line lobe
复制标题
斑尾鱼电感觉侧线叶的结构组织
DOI：
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发表时间：
1999
影响因子：
2.8
通讯作者：
Curtis C. Bell
中科院分区：
文献类型：
--
作者：
J. Meek;Kirsty Grant;Curtis C. Bell
硬骨鱼的电感觉侧线叶（ELL）是电感觉输入处理的第一个中心阶段。它是一个发育良好的结构，有六个主要层，位于菱形脑的顶部。其主要层由浅到深依次为分子层、神经节层、丛状层、颗粒层、中间层和深层纤维层。一个重要的输入来自电感受器，但必然的电动机指令信号和本体感觉、机械感觉侧线和下行电感觉反馈输入也到达ELL。ELL输入至少由14种细胞类型处理，它们经常对不同的输入表现出塑性响应。大的神经节细胞和大的梭状细胞为ELL投射细胞。它们是谷氨酸能的，投射到峡突核和中脑外侧核。中间神经元位于所有ELL层中，大多数是gaba能神经元。最显著的中间神经元是中间层的大多极细胞，其有髓鞘树突使突触前终末与颗粒细胞接触。关于ELL的突触组织和微电路，使用电子显微镜和细胞内标记技术已经阐明了许多定性和定量方面。然而，初级传入输入影响ELL投射细胞的途径仍不确定：初级传入似乎不直接接触大梭状细胞或大神经节细胞，但似乎只终止于颗粒细胞，其轴突特性尚不清楚。因此，更多关于ELL结构组织的信息对于详细了解mormords可塑性电感觉输入加工的神经基础仍然是必要的。
The electrosensory lateral line lobe (ELL) of mormyrid teleosts is the first central stage in electrosensory input processing. It is a well-developed structure with six main layers, located in the roof of the rhombencephalon. Its main layers are, from superficial to deep, the molecular, ganglionic, plexiform, granular, intermediate and deep fiber layers. An important input arises from electroreceptors, but corollary electromotor command signals and proprioceptive, mechanosensory lateral line and descending electrosensory feedback inputs reach the ELL as well. The ELL input is processed by at least 14 cell types, which frequently show plastic responses to different inputs. The large ganglionic and large fusiform cells are the ELL projection cells. They are glutamatergic and project to the isthmic preeminential nucleus and the midbrain lateral toral nucleus. Interneurons are located in all ELL layers and are mostly GABAergic. The most remarkable interneurons are large multipolar cells in the intermediate layer, which have myelinated dendrites making presynaptic terminals contacting granular cells. With respect to the synaptic organization and microcircuitry of the ELL, a number of qualitative and quantitative aspects have been elucidated using electron microscopical and intracellular labeling techniques. However, the pathways by which primary afferent input influences the ELL projection cells are still undetermined: primary afferents do not seem to contact large fusiform or large ganglionic cells directly, but seem to terminate exclusively on granular cells, the axonal properties of which are not known. Consequently, more information of the structural organization of the ELL is still necessary for a detailed understanding of the neural basis of the plastic electrosensory input processing in mormyrids.