Chemokines: more than just road signs
Chemokines: more than just road signs
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DOI：
10.1038/nri1776
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发表时间：
2006-02-01
影响因子：
100.3
通讯作者：
Marsland, BJ
中科院分区：
文献类型：
--
作者：
Bachmann, MF;Kopf, M;Marsland, BJ
长期以来，人们都知道趋化因子在体内协调树突细胞的迁移。然而，最近的证据表明，趋化因子不仅指导树突状细胞的运输，而且还可以调节其成熟状态。在这里，我们提出，这种双重功能的趋化因子，确保T细胞和树突状细胞满足T细胞区域的淋巴器官和抗原的免疫最佳的背景下，T细胞引发。
Chemokines have long been known to orchestrate dendritic-cell migration in the body. However, recent evidence has shown that chemokines not only direct the trafficking of dendritic cells but also can regulate their maturation status. Here, we propose that this dual function of chemokines ensures that T cells and dendritic cells meet in T-cell regions of lymphoid organs and that antigen is presented in an immunologically optimal context for T-cell priming.