Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering
Electrospun Nanofibers Containing Strontium for Bone Tissue Engineering
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用于骨组织工程的含锶电纺纳米纤维
DOI：
10.1155/2020/1257646
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发表时间：
2020
影响因子：
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通讯作者：
Zhou Qihui
中科院分区：
文献类型：
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作者：
Zhang Qi;Ji Yanjing;Zheng Weiping;Yan Mingzhe;Wang Danyang;Li Min;Chen Junbo;Yan Xiao;Zhang Qiang;Yuan Xiao;Zhou Qihui
电纺聚合物/金属复合纳米纤维由于具有细胞外基质样结构、足够的机械强度、良好的生物学性能和骨诱导作用，在骨组织工程和再生医学（BTERM）领域受到广泛关注。特别是含锶（Sr）的静电纺丝纳米纤维可以通过介导骨溶解和骨生成显著促进骨修复和再生，这为BTERM提供了一种很有前途的生物活性材料。本文就含锶电纺纳米纤维对骨髓基质细胞（BTERM）中干细胞、成骨细胞和破骨细胞的影响作一综述。此外，目前的挑战和未来的前景，静电纺丝含锶在BTERM的简要概述。希望本文的系统综述能启发读者进一步研究含锶纳米纤维用于BTERM的方法，并加速其从实验室到临床的转化。
Electrospun polymer/metal composite nanofibers have received much attention in the field of bone tissue engineering and regenerative medicine (BTERM) owing to their extracellular matrix- (ECM-) like structure, sufficient mechanical strength, favorable biological properties, and bone induction. In particular, electrospun nanofibers containing strontium (Sr) can significantly promote bone repair and regeneration by mediating osteolysis and osteogenesis, which offers a promising bioactive material for BTERM. In this review, we summarized the effects of electrospun nanofibers containing Sr on stem cells, osteoblasts, and osteoclasts in BTERM. Also, current challenges and future perspectives for electrospun nanofibers containing Sr in BTERM are briefly outlined. It is hoped that the systematic overview will inspire the readers to further study Sr-containing nanofibers for BTERM and accelerate their translation from the bench to the clinic.