Long-term effect of the internet-based glucose monitoring system on HbA1c reduction and glucose stability
Long-term effect of the internet-based glucose monitoring system on HbA1c reduction and glucose stability
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DOI：
10.2337/dc05-2371
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发表时间：
2006-12-01
期刊：
影响因子：
16.2
通讯作者：
Yoon, Kun-Ho
中科院分区：
文献类型：
--
作者：
Cho, Jae-Hyoung;Chang, Sang-Ah;Yoon, Kun-Ho
目的：探讨基于互联网的血糖监测系统(IBGMS)对2型糖尿病患者血糖控制的长期有效性。研究设计与方法：我们对80例2型糖尿病患者进行了为期30个月的前瞻性、随机、对照试验。干预组接受IBGMS治疗，而对照组仅进行常规的办公室访视。糖化血红蛋白(1c)、糖化血红蛋白(A1c)每隔3个月进行一次。结果：干预组(n=40)糖化血红蛋白(A1C)和糖化血红蛋白波动指数(HFI)均显著低于对照组(n=40)。(A1C[均值+/-SD]6.9+/-0.9vs.7.5+/-1.0%，P=0.009，HFI0.47+/-0.23vs.0.78+/-0.51，P=0.001；干预组与对照组比较)。基础糖化血红蛋白水平为7%(n=27)的干预组患者前3个月的糖化血红蛋白水平明显低于对照组，并在整个研究过程中保持较稳定的水平(P=0.022)。基础糖化血红蛋白水平为7%的对照组患者(n=15)的糖化血红蛋白水平呈现典型的双峰分布，而干预组的糖化血红蛋白水平在整个研究过程中保持稳定，且高密度脂蛋白水平较低。结论：长期使用IBGMS在控制血糖和实现血糖稳定方面已被证明优于基于办公室访问的传统糖尿病护理系统。
OBJECTIVE - To investigate the long-term effectiveness of the Internet-based glucose monitoring system (IBGMS) on glucose control in patients with type 2 diabetes.RESEARCH DESIGN AND METHODS - We conducted a prospective, randomized, controlled trial in 80 patients with type 2 diabetes for 30 months. The intervention group was treated with the IBGMS, while the control group made conventional office visits only. HbA(1c), (A1C) was performed at 3-month intervals. For measuring of the stability of glucose control, the SD value of A1C levels for each subject was used as the A1C fluctuation index (HFI).RESULTS- The mean A1C and HFI were significantly lower in the intervention group (n = 40) than in the control group (n = 40). (A1C [mean +/- SD] 6.9 +/- 0.9 vs. 7.5 +/- 1.0%, P = 0.009 HFI 0.47 +/- 0.23 vs. 0.78 +/- 0.51, P = 0.001; intervention versus control groups, respectively). Patients in the intervention group with a basal A1C >= 7% (n = 27) had markedly lower AIC levels than corresponding patients in the control group during the first 3 months and maintained more stable levels throughout the study (P = 0.022). Control patients with a basal A1C < 7% (n = 15) showed the characteristic bimodal distribution of A1C levels, whereas the A1C levels in the intervention group remained stable throughout the study with low HFI.CONCLUSIONS - Long-term use of the IBGMS has proven to be superior to conventional diabetes care systems based on office visits for controlling blood glucose and achieving glucose stability.