Role of Inhibins in Childhood and Puberty
Role of Inhibins in Childhood and Puberty
复制标题
抑制素在儿童期和青春期的作用
DOI：
10.1515/jpem.2001.14.4.343
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发表时间：
2001
影响因子：
1.4
通讯作者：
S. Campo
中科院分区：
文献类型：
--
作者：
I. Bergadá;C. Bergadá;S. Campo
主要在性腺中产生的抑制素抑制FSH的合成。已提出生物活性二聚体形式的Sertoli和颗粒细胞功能的外周标志物的Sertoli和B。从出生到成年期的血清二聚体的测定反映了男性和女性中两种二聚体的不同模式。伴随着促性腺激素激增，在出生后的头几个月观察到了一个重要的促性腺激素B的产生。在男性中，Escherichin B水平高于女性，并持续升高至儿童期，而在女性中，它们在6个月龄时下降至青春期前水平。在女孩中，在出生后的头两个月观察到高水平的血清白蛋白A;此后，直到青春期才检测到。在最大LHRH脉冲发生器抑制期间，雄性和雌性动物都持续有一种活跃的促性腺激素B分泌;然而，这种分泌可能依赖于促性腺激素仍然存在争议。在青春期，男性和女性的血清中白蛋白B的逐渐升高伴随着性类固醇的产生增加。在女孩中观察到类似的分泌模式。这种增加主要由促性腺激素产生，并由卵巢和睾丸内的多种旁分泌/自分泌机制调节，这些机制在整个青春期成熟过程中调节BMP 2亚基的二聚化。从出生到青春期，在男性和女性中观察到的与促性腺激素和性类固醇浓度相关的循环二聚体β-受体结合蛋白之间的差异为人类生殖研究开辟了新的视角。这些新的标志物可能有助于更好地了解下丘脑-垂体-性腺轴功能的调节和性分化和/或生育障碍的生理病理学机制。
Inhibins, produced mainly in the gonads, suppress FSH synthesis. The bioactive dimeric forms of inhibin (A and B) have been proposed as peripheral markers of Sertoli and granulosa cell function. The determination of serum dimeric inhibins from birth through adulthood reflects a distinct pattern of both inhibins in males and females. Concomitantly with the gonadotrophin surge, an important production of inhibin B is observed during the first months of life. In males, inhibin B levels are higher than in females and persist elevated up to childhood, whereas in females they decrease up to prepubertal levels by 6 months of age. In girls, high serum levels of inhibin A are observed during the first two months of life; thereafter, they are undetectable until puberty. An active secretion of inhibin B persists in both males and females in the period of maximal LHRH pulse generator restraint; however, the possible gonadotrophin dependence of this production remains controversial. At puberty, a progressive rise in serum inhibin B occurs concomitantly with the increased production of sex steroids in both males and females. A similar secretion pattern of inhibin A is observed in girls. This increment is mainly exerted by gonadotrophins and modulated by multiple paracrine/autocrine mechanisms within the ovary and the testis that regulate the dimerization of the inhibin subunits throughout pubertal maturation. The differences observed in males and females between circulating dimeric inhibins in relation to gonadotrophins and sex steroid concentrations from birth through puberty has opened a new perspective for research in human reproduction. These new markers may contribute to a better knowledge of the regulation of the hypothalamic-pituitary-gonadal axis function and the physiopathology of the mechanisms involved in sexual differentiation and/or fertility disorders.
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促性腺激素释放激素 (GnRH) 缺乏的男性在长期 GnRH 替代之前和期间的抑制素 B 分泌：与自发性青春期、睾丸体积和先前治疗的关系 - 一项临床研究中心研究。
DOI：
10.1210/jcem.81.10.8855795
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Nachtigall,LB;Boepple,PA;Seminara,SB;Khoury,RH;Sluss,PM;Lecain,AE;CrowleyJr,WF
通讯作者：
CrowleyJr,WF
促性腺激素释放激素 (GnRH) 缺乏的男性中的抑制素 B：短期生理性 GnRH 替代后血清浓度的变化 - 一项临床研究中心研究。
DOI：
10.1210/jcem.81.10.8855824
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism
影响因子：
--
作者：
Seminara,SB;Boepple,PA;Nachtigall,LB;Pralong,FP;Khoury,RH;Sluss,PM;Lecain,AE;CrowleyJr,WF
通讯作者：
CrowleyJr,WF
抑制素A和抑制素B与卵泡刺激激素呈负相关，但在大鼠动情周期的卵泡期却不一致，并且抑制素A以性别二态性方式表达。
影响因子：
4.8
作者：
Woodruff,TK;Besecke,LM;Groome,N;Draper,LB;Schwartz,NB;Weiss,J
通讯作者：
Weiss,J
影响因子：
4.8
作者：
PATRICIA L. Morris;W. Vale;Scott Cappel;C. W. Bardin
通讯作者：
PATRICIA L. Morris;W. Vale;Scott Cappel;C. W. Bardin
雄性大鼠抑制素的生理作用、含量和免疫染色随年龄变化。
影响因子：
4.8
作者：
Rivier,C;Cajander,S;Vaughan,J;Hsueh,AJ;Vale,W
通讯作者：
Vale,W