Testing for gene-gene interaction in case-control GWAS
Testing for gene-gene interaction in case-control GWAS
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DOI：
10.4310/sii.2017.v10.n2.a10
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发表时间：
2017-01-01
影响因子：
0.8
通讯作者：
Chen, Zhongxue
中科院分区：
文献类型：
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作者：
Chen, Zhongxue
检测基因间的相互作用是全基因组关联研究中一项重要而又具有挑战性的任务。为此，文献中提出了许多统计方法。然而，强大而有力的方法尚待开发。在本文中，我们研究了病例对照GWAS的基因-基因交互作用测试。对于给定的情况，可以构造许多强大的测试。我们还讨论了一些测试的主要影响和整体测试之间的关联基因型和表型。进行了模拟研究，以比较一些建议的测试与现有的方法。一个真实的数据的应用程序也进行说明所提出的测试的使用。
Detecting gene-gene interaction is an important but challenging task in genome-wide association studies (GWASs). To this end, many statistical methods have been proposed in the literature. However, powerful yet robust approaches are yet to be developed. In this paper we study the gene-gene interaction tests for case-control GWASs. A number of powerful tests can be constructed for given situations. We also discuss some tests for the main effects and the overall tests for association between genotype and phenotype. A simulation study is conducted to compare some of the proposed tests with existing methods. A real data application is also conducted to illustrate the use of the proposed tests.