Pd-catalyzed Kumada-Corriu cross-coupling reactions at low temperatures allow the use of Knochel-type Grignard reagents
Pd-catalyzed Kumada-Corriu cross-coupling reactions at low temperatures allow the use of Knochel-type Grignard reagents
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DOI：
10.1021/ja070830d
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发表时间：
2007-04-04
影响因子：
15
通讯作者：
Buchwald, Stephen L.
中科院分区：
文献类型：
--
作者：
Martin, Ruben;Buchwald, Stephen L.
描述了一种能够在低至-65摄氏度的温度下操作用于钯催化的Kumada-Corriu交叉偶联反应的催化剂系统。这种前所未有的活性水平允许使用高度官能化的（Knochel型）格氏试剂。此外，该方案对各种官能团的耐受性允许合成有价值的化合物，包括杂环或多氟联芳基。
A catalyst system able to operate at temperatures as low as -65 degrees C for the Pd-catalyzed Kumada-Corriu cross-coupling reaction is described. This unprecedented level of activity allows the use of highly functionalized (Knochel-type) Grignard reagents. Additionally, the tolerance of the protocol toward a wide variety of functional groups allows for the synthesis of valuable compounds, including heterocyclic or polyfluoro biaryls.