BASAL LINEAR DEPOSIT IN THE HUMAN MACULA
BASAL LINEAR DEPOSIT IN THE HUMAN MACULA
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DOI：
10.1007/bf02154735
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发表时间：
1986-01-01
影响因子：
2.7
通讯作者：
LEE, WR
中科院分区：
文献类型：
--
作者：
LOFFLER, KU;LEE, WR
我们用电子显微镜和免疫组化研究9个摘除老年人眼睛的黄斑区，并记录存在于所谓的基底线性存款的各种异常。这些变化包括从视网膜色素上皮基底膜突出的电子致密物质的类纤维束，宽带胶原蛋白、囊泡样成分、膜结合结构和偶尔的黑色素颗粒的沉积。在基底线状存款和Bruch膜中也发现了纤连蛋白，但未发现粘多糖。电子空空间的存在表明水渗透性的干扰。我们的研究还显示，在基底线性存款丰富的位置，视网膜色素上皮下的新生血管形成，以及巨噬细胞和内皮细胞过程对布鲁赫膜的侵蚀。我们的研究结果表明，基底线性存款是一个重要的先驱新生血管。可能的发病机制进行了讨论。
We used electron microscopy and immunohistochemistry to study the macular regions of nine enucleated elderly human eyes and to document the various abnormalities present in the so-called basal linear deposit. These changes include bush-like strands of electron-dense material, which project from the basement membrane of the retinal pigment epithelium, deposition of wide-banded collagen, vesiculoid elements, membrane-bound structures and occasional melanin granules. Fibronectin was also identified in the basal linear deposit and in Bruch''s membranes, but mucopolysaccharides could not be demonstrated. The presence of electron-empty spaces suggests a disturbance in water permeability. Our studies also showed neovascularisation beneath the retinal pigment epithelium in locations where the basal linear deposit was abundant, as well as erosion of Bruch''s membrane by macrophages and endothelial cell processes. Our findings suggest that the basal linear deposit is an important precursor neovascularisation. Possible pathogenetic mechanisms are discussed.