The Essential Role of Neutrophils during Infection with the Intracellular Bacterial Pathogen Listeria monocytogenes.
The Essential Role of Neutrophils during Infection with the Intracellular Bacterial Pathogen Listeria monocytogenes.
复制标题
DOI：
10.4049/jimmunol.1600599
复制
发表时间：
2016-09-01
期刊：
影响因子：
--
通讯作者：
Berg RE
中科院分区：
文献类型：
--
作者：
Witter AR;Okunnu BM;Berg RE
嗜中性粒细胞历来被表征为对宿主存活至关重要的第一反应细胞，这是由于它们具有遏制和消除细菌和真菌病原体的能力。然而，最近的研究表明，中性粒细胞参与保护和有害的反应，以各种各样的炎症和感染性疾病。虽然中性粒细胞对细胞外感染的贡献已经研究了几十年，但它们在细胞内细菌感染中的特定作用直到最近才被认识到。在革兰氏阳性细胞内病原体单核细胞增生李斯特菌感染期间，中性粒细胞从骨髓募集到感染部位，在那里它们利用新的细菌传感途径导致吞噬作用和杀菌因子的产生。本文综述了单核细胞增生李斯特菌感染过程中中性粒细胞的需求，通过检查原发性和继发性感染过程中中性粒细胞的运输和功能。
Neutrophils have historically been characterized as first responder cells vital to host survival due to their ability to contain and eliminate bacterial and fungal pathogens. However, recent studies have shown that neutrophils participate in both protective and detrimental responses to a diverse array of inflammatory and infectious diseases. Although the contribution of neutrophils to extracellular infections has been investigated for decades, their specific role during intracellular bacterial infections has only recently been appreciated. During infection with the gram-positive intracellular pathogen Listeria monocytogenes, neutrophils are recruited from the bone marrow to sites of infection where they utilize novel bacterial sensing pathways leading to phagocytosis and production of bactericidal factors. This review summarizes the requirement of neutrophils during Listeria monocytogenes infection by examining both neutrophil trafficking and function during primary and secondary infection.