Taste dysfunction in irradiated patients with head and neck cancer.
Taste dysfunction in irradiated patients with head and neck cancer.
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受辐射的头颈癌患者的味觉功能障碍。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
S. Komiyama
中科院分区：
文献类型：
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作者：
Wen;A. Inokuchi;Tomoya Yamamoto;S. Komiyama
头颈癌放射治疗引起的味觉障碍很常见。这项针对40名头颈癌患者的前瞻性研究评估了放射治疗期间味觉的变化。研究了时程与味觉障碍程度的关系。在放射治疗前、中、后，采用全口味法测量四种基本味觉的味觉识别阈值和阈值以上的味觉强度表现。苦味受影响最大。甜味阈值的提高取决于舌尖是否包括在辐射场中。在放射治疗期间或之后，味觉强度表现的斜率没有改变。唾液功能障碍模式与味觉功能障碍模式不同。辐射期间味觉障碍的主要原因支持味觉障碍是由于辐射场中味蕾受损的假说。
Taste disorders caused by radiation therapy for head and neck cancer are common. This prospective study of 40 patients with head and neck cancer assessed changes in taste sensations during radiation therapy. The relationship between the time course and the degree of taste disorder was studied. The taste recognition threshold and supra-threshold taste intensity performance for the four basic tastes were measured using the whole-mouth taste method before, during, and after radiation therapy. Bitter taste was affected most. An increase in threshold for sweet taste depended upon whether the tip of tongue was included within the radiation field. The slope of the taste intensity performance did not change during or after radiotherapy. The pattern of salivary dysfunction was different from that of taste dysfunction. The main cause of taste disorders during radiation support the hypothesis that taste dysfunction is due to damage to the taste buds in the radiation field.