Sources of Auditory Brainstem Responses Revisited: Contribution by Magnetoencephalography
Sources of Auditory Brainstem Responses Revisited: Contribution by Magnetoencephalography
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DOI：
10.1002/hbm.20788
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发表时间：
2009-06-01
影响因子：
4.8
通讯作者：
Makela, Jyrki R.
中科院分区：
文献类型：
--
作者：
Parkkonen, Lauri;Fujiki, Nobuya;Makela, Jyrki R.
听觉脑干反应提供诊断价值的病理涉及早期部分的听觉通路。尽管如此，这些反应的各个组成部分背后的神经发生器仍然不清楚。人类的直接电记录只可能在手术期间的有限时间内和从患病大脑的小区域进行。因此，发生器部位的证据是零散和间接的，主要基于病变研究和动物模型。EEG的源建模一直限于多个受试者的总平均值。在这里，我们采用脑磁图（MEG）来阐明听觉脑干反应（ABR）的神经起源，并测试这种深部脑结构是否可以被MEG访问。我们表明，磁对应的电ABR可以在30分钟内测量，他们允许本地化的一些潜在的神经源在个别科目。在我们的MEG数据中存在许多电ABR分量;然而，磁响应和电响应的形态是不同的，这表明MEG信号携带与EEG数据互补的信息。ABR磁偏转所对应的神经源的位置范围从听神经到下丘。最早的皮质反应在13 ms的潜伏期时可检测到。《脑地图》30：1772-1782，2009。(C)2009威利-利斯公司
Auditory brainstem responses provide diagnostic value in pathologies involving the early parts of the auditory pathway. Despite that, the neural generators underlying the various components of these responses have remained unclear. Direct electrical recordings in humans are possible only in limited time periods during surgery and from small regions of the diseased brains. The evidence of the generator sites is therefore fragmented and indirect, based strongly on lesion studies and animal models. Source modeling of EEG has been limited to grand averages across multiple subjects. Here, we employed magnetoencephalography (MEG) to shed more light on the neural origins of the auditory brainstem responses (ABR) and to test whether such deep brain structures are accessible by MEG. We show that the magnetic counterparts of the electric ABRs can be measured in 30 min and that they allow localization of some of the underlying neural sources in individual subjects. Many of the electric ABR components were present in our MEG data; however, the morphologies of the magnetic and electric responses were different, indicating that the MEG signals carry information complementary to the EEG data. The locations of the neural sources corresponding to the magnetic ABR deflections ranged from the auditory nerve to the inferior colliculus. The earliest cortical responses were detectable at the latency of 13 ms. Hum Brain Mapp 30:1772-1782, 2009. (C) 2009 Wiley-Liss, Inc.