Prevalence of pesticide exposure in young males (
Prevalence of pesticide exposure in young males (
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DOI：
10.1186/1477-3163-2-4
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发表时间：
2003-07-15
影响因子：
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通讯作者：
Langness, Eric
中科院分区：
文献类型：
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作者：
Potti, Anil;Panwalkar, Amit W;Langness, Eric
有证据表明农药是前列腺癌的致病因素，这一点存在争议，具体地说，缺乏年轻人的数据。因此，我们进行了一项初步研究，评估年轻男性接触杀虫剂与前列腺癌的关系。在北达科他州大学机构审查委员会和人类受试者委员会批准后，对所有年轻男性进行了一项回溯性研究(2400小时被视为“暴露”)。2400小时的截止值是根据以前的报告选择的，这些报告表明这个数字代表着严重接触遗传毒性物质。采用SPSS-10ledR；软件进行统计学分析。1991年至2001年，61名年轻男性前列腺癌患者被确诊，其中56名患者平均年龄47岁(40-49岁)，有完整的治疗记录，可联系以完成问卷调查。临床表现最常见的阶段是III期，Gleason评分平均为7.5分(5-9分)。有趣的是，几乎三分之一(16/56，28.6%)的患者在发病时有IV期疾病。在我们的研究中，37/56(66.1%)患者有明显的暴露。此外，有趣的是，接触农药的患者的平均生存期为11.3个月(SD：+/-2.3个月)，而未接触农药的患者(n=19)的平均生存期为20.1个月(SD：+/-3.1个月)，p值为
Evidence implicating pesticides as causative agents of prostate cancer is controversial, and specifically, data in young adults is lacking. Hence, we performed a preliminary study evaluating the relationship between pesticide exposure and prostate cancer in young males. After approval from the University of North Dakota Institutional Review Board and Human Subjects Committee, a retrospective study was performed on all young males (2400 hours were considered as 'exposed.' The 2400 hour cut-off value was chosen on the basis of previous reports indicating that this figure represents heavy exposure to genotoxic agents. Statistical analysis was obtained using SPSS-10ledR;. Between 1991 and 2001, 61 young males with adenocarcinoma of the prostate were identified, of whom 56 patients with a mean age of 47 years (range: 40-49) had complete records of treatment and could be contacted for completion of the questionnaire. The most common stage at presentation was Stage III and the mean Gleason's score was 7.5 (range 5-9). Interestingly, almost a third (16/56, 28.6%) of patients had stage IV disease at presentation. 37/56 (66.1%) patients had 'significant' exposure in our study. In addition, interestingly, the mean survival in the subgroup of patients with pesticide exposure was 11.3 months (SD: +/- 2.3 months), while the mean survival in the patients without pesticide exposure (n = 19) was 20.1 months (SD: +/- 3.1 months), with p-value