HIGH-RISK HUMAN PAPILLOMAVIRUS AND CERVICAL LYMPH NODE METASTASIS IN PATIENTS WITH OROPHARYNGEAL CANCER
HIGH-RISK HUMAN PAPILLOMAVIRUS AND CERVICAL LYMPH NODE METASTASIS IN PATIENTS WITH OROPHARYNGEAL CANCER
复制标题
DOI：
10.1002/hed.21697
复制
发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Kim, Min-Sik
中科院分区：
文献类型：
--
作者：
Joo, Young-Hoon;Jung, Chan-Kwon;Kim, Min-Sik
背景本研究旨在探讨高危型人乳头瘤病毒（HPV）在口咽癌淋巴结转移和浸润深度中的作用。该研究包括90例口腔癌和66例口咽癌患者。采用高危型HPV原位杂交检测HPV感染。高危型HPV原位杂交阳性率为15.4%（24/156）。口腔癌（6.7%）和口咽癌（27.3%）之间的高危型HPV阳性率存在显著差异（p <0.000）。在口咽癌患者中，高危型HPV阳性与颈淋巴结转移、肿瘤浸润深度之间存在显著相关性（分别为p = 0.002、p = 0.016）。口咽癌患者高危型HPV阳性与疾病特异性生存率之间存在统计学显著相关性（p = 0.035）。高危型HPV感染与口咽癌患者的颈淋巴结转移和浸润深度显著相关。(C)2011 Wiley Periodicals，Inc.头颈34：10-14，2012
Background. The purpose of this study was to determine the role of high-risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer.Methods. The study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. High-risk HPV in situ hybridization was performed to detect HPV infection.Results. The positive rate of high-risk HPV in situ hybridization was 15.4% (24 of 156). There was a significant difference in the fraction of positive high-risk HPV between oral (6.7%) and oropharyngeal (27.3%) cancers (p < .000). Significant correlations were found between positive high-risk HPV and cervical lymph node metastasis, tumor depth of invasion in patients with oropharyngeal cancer (p = .002, p = .016, respectively). There was a statistically significant association between high-risk HPV positivity and the disease-specific survival in patients with oropharyngeal cancer (p = .035).Conclusion. High-risk HPV infection was significantly related to cervical lymph node metastasis and depth of invasion in patients with oropharyngeal cancer. (C) 2011 Wiley Periodicals, Inc. Head Neck 34: 10-14, 2012