The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing
The Exosome - A Naturally Secreted Nanoparticle and its Application to Wound Healing
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DOI：
10.1002/adma.201504009
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发表时间：
2016-07-20
影响因子：
29.4
通讯作者：
Ritter, Thomas
中科院分区：
文献类型：
--
作者：
Rani, Sweta;Ritter, Thomas
伤口愈合是一个复杂的过程，在患有基础慢性疾病的患者中通常会延迟。伤口护理的成本是社会的重大负担，需要新技术来促进伤口愈合。一些研究已经报道了间充质干细胞（MSC）在募集宿主细胞、释放分泌因子和基质蛋白从而促进伤口愈合方面的有益作用。这些从MSC分泌生物活性营养因子还包括细胞外囊泡（EV）或外来体。最近的研究表明，EV是MSC介导细胞间通讯以促进伤口愈合的关键分泌产物之一。目前的知识有关的潜在用途电动汽车在伤口愈合的审查和电动汽车-一种天然分泌的纳米粒子-作为替代细胞为基础的治疗的前景进行了讨论。
Wound healing is a complex process and often delayed in patients with underlying chronic conditions. The cost of wound care is a significant burden to the society, warranting new techniques to prompt wound healing. Several studies have reported on the beneficial effects of mesenchymal stem cells (MSCs) function in recruiting host cells, releasing secretory factors and matrix proteins thereby increasing wound heal. These secrete bioactive trophic factors from MSCs also includes extracellular vesicles (EVs) or exosomes. Recent studies have shown that EVs are one of the key secretory products of MSCs mediating cell-to-cell communication to enhance wound healing. Current knowledge related to the potential use of EVs in wound healing is reviewed and the promising future for EVs - a naturally secreted nanoparticle - as an alternative to cell-based therapy is discussed.