Polypurine tract adjacent to the U3 region of the Rous sarcoma virus genome provides a cis-acting function.
Polypurine tract adjacent to the U3 region of the Rous sarcoma virus genome provides a cis-acting function.
复制标题
与劳斯肉瘤病毒基因组 U3 区域相邻的多嘌呤区提供顺式作用功能。
DOI：
10.1128/jvi.43.2.482-488.1982
复制
发表时间：
1982
影响因子：
5.4
通讯作者：
Hughes,SH
中科院分区：
文献类型：
--
作者：
Sorge,J;Hughes,SH
The v-src coding region was deleted from cloned Rous sarcoma virus DNA, and the deleted clones were tested for infectivity by transfection. All of the coding region, as well as most of the sequences lying between v-src and the unique 3' region (U3), could be deleted without affecting viability. However, at least 9 and at most 29 of the nucleotides in the purine-rich tract adjacent to U3 were necessary for growth, even in the presence of a helper virus. It is concluded that these nucleotides (the polypurine tract) provide a cis-acting function necessary for retrovirus replication.
