Remodelling the attentional system after left hemispheric stroke: Effect of leftward prismatic adaptation
Remodelling the attentional system after left hemispheric stroke: Effect of leftward prismatic adaptation
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DOI：
10.1016/j.cortex.2019.01.007
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发表时间：
2019-06-01
期刊：
影响因子：
3.6
通讯作者：
Clarke, Stephanie
中科院分区：
文献类型：
--
作者：
Crottaz-Herbette, Sonia;Tissieres, Isabel;Clarke, Stephanie
已知左半球中风与右忽视和/或不侧化注意力缺陷相关。前者似乎对大面积左中风病例报告的L-PA适应反应良好。在正常受试者中，短暂暴露于L-PA被证明可以增强右顶下小叶内右视野的代表性，从而强调腹侧注意系统内的右半球优势。我们通过比较短暂暴露于L-PA之前和之后对左侧、中枢和右侧刺激的神经反应，研究了L-PA是否在左半球中风中具有相同的作用。对视觉刺激的神经反应在枕颞皮层的大部分区域内以及在角回、前颞叶和小脑中的较小集群内被显著调制，对应于活动的减少。在枕-颞区内，这种减少主要涉及由左侧刺激引起的神经活动，从而下调对侧视野的表示，这是该区域高阶视觉区的特征。(C)2019爱思唯尔有限公司版权所有。
Left hemispheric stroke is known to be associated with right neglect and/or not lateralized attentional deficits. The former appears to respond favourably to leftward prismatic adaptation (L-PA), as reported in a case of a large left stroke. In normal subjects, brief exposure to L-PA was shown to enhance the representation of the right visual field within the right inferior parietal lobule, emphasizing thus right hemispheric dominance within the ventral attentional system. We have investigated whether L-PA does the same in left hemispheric stroke by comparing neural responses to left, central and right stimuli before and after a brief exposure to L-PA. Neural responses to visual stimuli were significantly modulated within a large part of the occipito-temporal cortex and in smaller clusters in the angular gyrus, the anterior temporal lobe and the insula, corresponding to decrease in activity. Within the occipito-temporal region the decrease concerned predominantly neural activity elicited by left stimuli, downregulating thus the representation of the contralateral visual field, which is characteristic of the higher-order visual areas in this region. (C) 2019 Elsevier Ltd. All rights reserved.