Longevity - Extending the lifespan of long-lived mice
Longevity - Extending the lifespan of long-lived mice
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DOI：
10.1038/35106646
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发表时间：
2001-11-22
期刊：
影响因子：
64.8
通讯作者：
Roth, GS
中科院分区：
文献类型：
--
作者：
Bartke, A;Wright, JC;Roth, GS
艾姆斯侏儒小鼠是一种突变小鼠，寿命比正常小鼠长50%，因为它们携带一种“长寿”基因Prop1df，在某些表型方面，它们与正常小鼠相似，后者的寿命因限制食物摄入而延长。在这里，我们调查这些因素是否影响寿命的相似或独立的机制，故意减少消耗的卡路里数量的艾姆斯侏儒小鼠。我们表明，热量限制赋予侏儒的寿命进一步增加，表明这两个因素可能通过不同的途径发挥作用。
Ames dwarf mice are mutant mice that live about 50% longer than their normal siblings,,because they carry a 'longevity' gene,Prop1df, and in some phenotypic respects they resemble normal mice whose lifespan has been extended by restricted food intake,,. Here we investigate whether these factors influence lifespan by similar or independent mechanisms, by deliberately reducing the number of calories consumed by Ames dwarf mice. We show that calorie restriction confers a further lifespan increase in the dwarfs, indicating that the two factors may act through different pathways.