Direct visualization of deep brain stimulation targets in Parkinson disease with the use of 7-tesla magnetic resonance imaging.
Direct visualization of deep brain stimulation targets in Parkinson disease with the use of 7-tesla magnetic resonance imaging.
复制标题
使用 7 特斯拉磁共振成像直接可视化帕金森病的深部脑刺激目标。
DOI：
10.3171/2010.3.jns091385
复制
发表时间：
2010-09
影响因子：
4.1
通讯作者：
Lee KH
中科院分区：
文献类型：
--
作者：
Cho ZH;Min HK;Oh SH;Han JY;Park CW;Chi JG;Kim YB;Paek SH;Lozano AM;Lee KH
深部脑刺激（DBS）治疗晚期帕金森病（PD）的一个挑战是直接可视化脑核，这通常涉及间接逼近立体定向目标。在本研究中，作者将7-T MR成像获得的T2*加权图像与1.5- t和3-T MR成像获得的T2*加权图像进行了比较，以确定7-T成像是否能更好地显示PD中DBS的目标。作者比较了11名健康志愿者和1名PD患者的1.5、3和7-T MR图像。通过7-T成像，获得了清晰的大脑图像，包括丘脑下核（STN）和内部苍白球（GPi）。与STN和GPi的1.5 t和3-T MR图像相比，7-T MR图像在空间分辨率、组织对比度和信噪比方面均有显著改善。本研究的数据揭示了7-T MR成像在PD治疗中对DBS靶向结构的可视化优势。这一发现表明，通过直接可视化感兴趣的神经结构，7-T磁共振成像可以在神经外科手术中提供有价值的帮助。
A challenge associated with deep brain stimulation (DBS) in treating advanced Parkinson disease (PD) is the direct visualization of brain nuclei, which often involves indirect approximations of stereotactic targets. In the present study, the authors compared T2*-weighted images obtained using 7-T MR imaging with those obtained using 1.5- and 3-T MR imaging to ascertain whether 7-T imaging enables better visualization of targets for DBS in PD. The authors compared 1.5-, 3-, and 7-T MR images obtained in 11 healthy volunteers and 1 patient with PD. With 7-T imaging, distinct images of the brain were obtained, including the subthalamic nucleus (STN) and internal globus pallidus (GPi). Compared with the 1.5- and 3-T MR images of the STN and GPi, the 7-T MR images showed marked improvements in spatial resolution, tissue contrast, and signal-to-noise ratio. Data in this study reveal the superiority of 7-T MR imaging for visualizing structures targeted for DBS in the management of PD. This finding suggests that by enabling the direct visualization of neural structures of interest, 7-T MR imaging could be a valuable aid in neurosurgical procedures.