Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty - A prospective, randomised, double-blind study of 86 patients
Fibrinolytic inhibition with tranexamic acid reduces blood loss and blood transfusion after knee arthroplasty - A prospective, randomised, double-blind study of 86 patients
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DOI：
10.1302/0301-620x.78b3.0780434
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发表时间：
1996-05-01
影响因子：
--
通讯作者：
Fredin, H
中科院分区：
文献类型：
--
作者：
Benoni, G;Fredin, H
我们通过一项对 86 名患者进行的随机、双盲研究，研究了纤溶抑制剂氨甲环酸对膝关节置换术中失血和输血的影响。在释放止血带前不久，静脉内给予氨甲环酸或安慰剂剂量为 10 毫克/公斤体重，并在三小时后重复。氨甲环酸的平均总失血量为 730 +/- 280 毫升安慰剂组为 1410 +/- 480 mi（p < 0.001）。治疗组接受输血的患者人数和输血单位数量均减少至三分之一，预防后平均术后 Nb 浓度显着升高。两组血栓栓塞并发症的数量相同，应预防性给予氨甲环酸才能有效。
We investigated the effect of a fibrinolytic inhibitor, tranexamic acid, on blood loss and blood transfusion in knee arthroplasty by a randomised, double-blind study of 86 patients, A dose of 10 mg/kg body-weight of either tranexamic acid or placebo was given intravenously shortly before the release of the tourniquet, and repeated three hours later, The mean total blood loss was 730 +/- 280 ml in the tranexamic acid group as against 1410 +/- 480 mi in the placebo group (p < 0.001).Both the number of patients receiving blood transfusion and the number of blood units transfused were reduced to one-third in the treated group, and mean postoperative Nb concentrations were significantly higher after prophylaxis. The number of thromboembolic complications was the same in both groups, Tranexamic acid should be given prophylactically in order to be effective.