Progress in microencapsulation of probiotics: A review.
Progress in microencapsulation of probiotics: A review.
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DOI：
10.1111/1541-4337.12532
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发表时间：
2020-02
影响因子：
14.8
通讯作者：
Mingfei Yao;Jiaojiao Xie;Hengjun Du;D. Mcclements;Hang Xiao;Lanjuan Li
中科院分区：
文献类型：
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作者：
Mingfei Yao;Jiaojiao Xie;Hengjun Du;D. Mcclements;Hang Xiao;Lanjuan Li
益生菌的潜在健康益处可能无法实现，因为它们在食物储存和胃肠道运输过程中的活力大幅降低。微囊化可用于增强益生菌对不利条件的抵抗力。为了提高到达结肠的益生菌水平，已经开发了一系列口服递送系统，包括包埋和涂层系统。本综述介绍了益生菌微胶囊化的新兴策略，并强调了其抗应激特性的关键机制。还回顾了最近用于评估益生菌递送系统效率的体外和体内模型。需要封装技术来维持益生菌在储存期间和在人体肠道内的活力，从而提高它们在结肠中定殖的能力。这些技术的作用是保护益生菌免受恶劣环境条件的影响，并提高其粘膜粘附特性。通常，益生菌要么嵌入内部，要么涂有食品级材料，例如生物聚合物或脂质。在某些情况下，可以共封装其他成分以增强其活力，例如营养物或保护剂。还强调了拥有合适的体外和体内模型来评估益生菌递送系统效率的重要性。
The potential health benefits of probiotics may not be realized because of the substantial reduction in their viability during food storage and gastrointestinal transit. Microencapsulation can be used to enhance the resistance of probiotics to unfavorable conditions. A range of oral delivery systems has been developed to increase the level of probiotics reaching the colon including embedding and coating systems. This review introduces emerging strategies for the microencapsulation of probiotics and highlights the key mechanisms of their stress-tolerance properties. Recent in vitro and in vivo models for evaluation of the efficiency of probiotic delivery systems are also reviewed. Encapsulation technologies are required to maintain the viability of probiotics during storage and within the human gut so as to increase their ability to colonize the colon. These technologies work by protecting the probiotics from harsh environmental conditions, as well as increasing their mucoadhesive properties. Typically, the probiotics are either embedded inside or coated with food-grade materials such as biopolymers or lipids. In some cases, additional components may be coencapsulated to enhance their viability such as nutrients or protective agents. The importance of having suitable in vitro and in vivo models to evaluate the efficiency of probiotic delivery systems is also emphasized.