Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study
Neural correlates of exposure to traumatic pictures and sound in Vietnam combat veterans with and without posttraumatic stress disorder: A positron emission tomography study
复制标题
DOI：
10.1016/s0006-3223(98)00297-2
复制
发表时间：
1999-04-01
影响因子：
10.6
通讯作者：
Charney, DS
中科院分区：
文献类型：
--
作者：
Bremner, JD;Staib, LH;Charney, DS
背景资料：创伤后应激障碍（PTSD）患者在暴露于创伤性图片和声音后，PTSD症状和生理反应会可靠地增加。在这项研究中，暴露于创伤性图片和声音的神经相关性被测量在PTSD.Methods：正电子发射断层扫描和H-2 [O-15]被用来测量脑血流量在暴露于战斗相关的和中性的图片和声音在越南战斗退伍军人与非PTSD。结果：创伤后应激障碍中的创伤性物质暴露（但不是非创伤后应激障碍）受试者导致内侧前额叶皮层（25区）的血流量减少，通过抑制杏仁核的反应而在情绪中起作用的区域。非PTSD受试者激活前扣带回（24区）比PTSD患者更大的程度。在涉及记忆和视觉空间处理（以及对威胁的扩展反应）的区域，包括后扣带回（23区），中央前（运动）和顶叶下皮层以及舌回，脑血流反应也存在差异。有一个模式的增加，在PTSD和减少非PTSD科目在these areas. Conclusions：研究结果表明，在特定的皮质和皮质下的大脑区域参与记忆，视觉空间处理，和情绪的功能改变的PTSD患者的症状。(C)1999年生物精神病学学会。
Background: Patients with posttraumatic stress disorder (PTSD) show a reliable increase in PTSD symptoms and physiological reactivity following exposure to traumatic pictures and sounds. In this study neural correlates of exposure to traumatic pictures and sounds were measured in PTSD.Methods: Positron emission tomography and H-2[O-15] were used to measure cerebral blood flow during exposure to combat-related and neutral pictures and sounds in Vietnam combat veterans with and without PTSD.Results: Exposure to traumatic material in PTSD (but not non-PTSD) subjects resulted in a decrease in blood flow in medial prefrontal cortex (area 25), an area postulated to play a role in emotion through inhibition of amygdala responsiveness. Non-PTSD subjects activated anterior cingulate (area 24) to a greater degree than PTSD patients. There were also differences in cerebral blood flow response in areas involved in memory and visuospatial processing (and by extension response to threat), including posterior cingulate (area 23), precentral (motor) and inferior parietal cortex, and lingual gyrus. There was a pattern of increases in PTSD and decreases in non-PTSD subjects in these areas.Conclusions: The findings suggest that functional alterations in specific cortical and subcortical brain areas involved in memory, visuospatial processing, and emotion underlie the symptoms of patients with PTSD. (C) 1999 Society of Biological Psychiatry.