Assessing user preferences for design characteristics of oral dissolvable strips for pediatric HIV medication: a qualitative study.
Assessing user preferences for design characteristics of oral dissolvable strips for pediatric HIV medication: a qualitative study.
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DOI：
10.1186/s12913-023-10078-6
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发表时间：
2023-10-16
影响因子：
2.8
通讯作者：
Finocchario-Kessler, Sarah
中科院分区：
文献类型：
--
作者：
Wexler, Catherine;Maloba, May;Sliefert, Michala;Babu, Shadrack;Maosa, Nicodemus;Maliski, Edward;Nicolay, Zachary;Were, Frederick;Mbithi, Yvonne;Mugendi, George;Thomas, Gregory;Acharya, Harshdeep;Finocchario-Kessler, Sarah
关键词：
目前的婴儿抗逆转录病毒治疗制剂由于复杂的基于体重的给药、明显的制备和差的适口性而对每日依从性构成障碍。这些依从性障碍危及依从性，使患者易受病毒学失败、耐药性发展和可预防的死亡的影响。我们的团队之前已经建立了多药物口服可溶性条带作为替代儿科抗逆转录病毒制剂的原理验证，有可能克服这些挑战并改善儿科ART依从性和结果。本研究的目的是评估护理人员和提供者对口腔可溶性条带及其包装的偏好，以告知其开发情况。在以用户为中心的设计理念的指导下，我们对30名艾滋病毒护理提供者进行了关键的知情人访谈，并针对肯尼亚3家医院10岁以下艾滋病毒感染儿童的护理人员进行了焦点小组讨论。关键的线人访谈和焦点小组讨论进行录音，逐字翻译/转录，并手动编码的先验和新兴的主题。共有30名提供者和72名照顾者（照顾83名5个月至18岁的儿童）参加了这项研究。护理人员和提供者表达了对更简单的给药方式的强烈愿望，特别是对于太小而不能整片吞下片剂的儿童，并对口服可溶性条带的想法表示了热情。主要偏好包括令人愉快的味道;每剂量一条;小尺寸快速溶解;清晰的标记和说明;没有特殊的储存要求。对于包装，利益相关者更喜欢在分配器内单独包装的条带。单个包装应耐用、防水，并易于在公共空间处理。它们也应该容易打开，并有明确的指示在哪里打开。保持条的包装应该是耐用的，可重复使用的，适应各种补充频率，并且易于为6岁的儿童使用。感染艾滋病毒儿童的护理人员和艾滋病毒护理提供者高度接受口服可溶性试纸的概念。通过让利益相关者参与从设计和开发的早期阶段开始的迭代设计过程，我们将最大限度地提高开发护理人员和婴儿可接受的产品的可能性，从而实现可持续的依从性。在线版本包含补充材料，可通过10.1186/s12913-023-10078-6获得。
Current infant antiretroviral therapy formulations pose barriers to daily adherence due to complex weight-based dosing, conspicuous preparation, and poor palatability. These adherence barriers jeopardize adherence, making patients vulnerable to virologic failure, development of drug resistance, and preventable mortality. Our team has previously established proof-of-principle for multi-drug oral dissolvable strips as alternative pediatric antiretroviral formulations with the potential to overcome these challenges and improve pediatric ART adherence and outcomes. The objective of this study was to assess caregiver and provider preferences for oral dissolvable strips and its packaging to inform its development. Guided by concepts of user-centered design, we conducted key informant interviews with 30 HIV care providers and focus group discussions targeting caregivers of children < 10 years of age living with HIV at 3 Kenyan hospitals. Key informant interviews and focus group discussions were audio recorded, translated/transcribed verbatim, and hand coded for a-priori and emergent themes. A total of 30 providers and 72 caregivers (caring for 83 children, aged 5 months to 18 years) participated in the study. Caregivers and providers expressed a strong desire for an easier way to administer medication, especially among children too young to swallow tablets whole, and expressed enthusiasm around the idea of oral dissolvable strips. Key preferences included a pleasant taste; one strip per dose; small size with rapid dissolution; clear markings and instructions; and no special storage requirements. For packaging, stakeholders preferred individually wrapped strips within a dispenser. The individual packaging should be durable, waterproof, and easy to dispose of in communal spaces. They should also be easy to open, with clear indications where to open. The packaging holding the strips should be durable, re-usable, accommodating of various refill frequencies, and easy to use for children as young as 6. The concept of oral dissolvable strips was highly acceptable to caregivers of children living with HIV and HIV care providers. By engaging stakeholders in an iterative design process starting from the early phases of design and development, we will maximize the likelihood of developing a product that is acceptable to the caregiver and infant, therefore leading to sustainable adherence. The online version contains supplementary material available at 10.1186/s12913-023-10078-6.
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DOI：
10.1186/1748-5908-4-50
发表时间：
2009-08-07
期刊：
Implementation science : IS
影响因子：
--
作者：
Damschroder LJ;Aron DC;Keith RE;Kirsh SR;Alexander JA;Lowery JC
通讯作者：
Lowery JC
影响因子：
3.7
作者：
Giralt, Ariadna Nebot;Nostlingerl, Christiana;Marchal, Bruno
通讯作者：
Marchal, Bruno
影响因子：
2.8
作者：
Mochache, Vernon;Irungu, Eunice;Gichangi, Peter
通讯作者：
Gichangi, Peter
DOI：
10.1097/qai.0000000000001743
发表时间：
2018-08-15
影响因子：
3.6
作者：
Penazzato, Martina;Irvine, Cadi;Doherty, Meg
通讯作者：
Doherty, Meg
影响因子：
4.9
作者：
Fetzer, Bradley C.;Mupenda, Bavon;Behets, Frieda
通讯作者：
Behets, Frieda