Flow-mediated dilatation
Flow-mediated dilatation
复制标题
DOI：
10.1046/j.1365-2125.2000.00277.x
复制
发表时间：
2000-11-01
影响因子：
3.4
通讯作者：
Celermajer, DS
中科院分区：
文献类型：
--
作者：
Raitakari, OT;Celermajer, DS
动脉内皮细胞功能障碍是动脉粥样硬化形成的关键早期事件之一，发生在结构性动脉粥样硬化改变之前。在梗阻性动脉粥样硬化的晚期，它也很重要，容易狭窄和/或血栓形成。冠状动脉和外周的内皮功能可以通过测量动脉内注入增强内皮一氧化氮释放的药物后的血管运动功能来测量。这些方法的缺点是它们的侵入性，这通常使它们不适合于涉及无症状受试者的研究。为此，血管内皮细胞功能的非侵入性检测已经发展起来。其中应用最广泛的是一种基于超声的方法，测量动脉直径是为了响应切应力的增加，这会导致内皮依赖性的扩张。用这种方法评估的内皮功能与冠状动脉内皮功能的侵入性测试相关，也与冠状动脉粥样硬化的严重程度和程度有关。这种无创的内皮功能检测为早期动脉粥样硬化的形成以及通过各种策略，包括药物(降脂、血管紧张素转换酶抑制)、L-精氨酸、抗氧化剂和激素对内皮功能障碍的潜在可逆性提供了有价值的见解。
Arterial endothelial dysfunction is one of the key early events in atherogenesis, preceding structural atherosclerotic changes. It is also important in the late stages of obstructive atherosclerosis, predisposing to constriction and/or thrombosis. Endothelial function can be measured in coronary arteries and in the periphery by measuring vasomotor function after intra-arterial infusion of pharmacologic substances which enhance the release of endothelial nitric oxide. The disadvantage of these methods is their invasive nature, which generally makes them unsuitable for studies involving asymptomatic subjects. For this reason, noninvasive tests of endothelial function have been developed. In the most widely used of these, an ultrasound-based method, arterial diameter is measured in response to an increase in shear stress, which causes endothelium-dependent dilatation. Endothelial function assessed by this method correlates with invasive testing of coronary endothelial function, as well as with the severity and extent of coronary atherosclerosis. This noninvasive endothelial function testing has provided valuable insights into early atherogenesis, as well as into the potential reversibility of endothelial dysfunction by various strategies, including pharmacological agents (lipid lowering, ACE inhibition), l-arginine, antioxidants and hormones.