Ambulatory Cardiovascular Activity and Hostility Ratings in Women with Chronic Posttraumatic Stress Disorder
Ambulatory Cardiovascular Activity and Hostility Ratings in Women with Chronic Posttraumatic Stress Disorder
复制标题
DOI：
10.1016/j.biopsych.2008.06.024
复制
发表时间：
2009-02-01
影响因子：
10.6
通讯作者：
Calhoun, Patrick S.
中科院分区：
文献类型：
--
作者：
Beckham, Jean C.;Flood, Amanda M.;Calhoun, Patrick S.
背景资料：本研究的目的是评估敌意和动态心血管活动之间的关系，在妇女和没有创伤后应激障碍（PTSD.Methods）：101名妇女完成了24小时的动态监测和标准化的诊断和敌意措施。采用广义估计方程分析（GeneralizedEstimatedEquations Analysis）方法，研究了群体和敌对因素（敌对信念、显性敌对和隐性敌对）对动态心率（AHR）、动态收缩压（ASBP）和动态舒张压（ADBP）的影响。与没有PTSD的女性相比，PTSD女性中敌意的增加与心率的增加有关。有一个敌对的信念和组ADBP.Conclusions之间的相互作用类似：AHR和血压的增加已与不良的心血管疾病的结果在非精神病人群。PTSD患者表现出更强的敌意，这一结构也与心血管预后不良有关。与对照组相比，PTSD女性中敌意信念的增加与ADBP的更大增加相关。这些数据表明，PTSD可能在一定程度上缓和敌意和心血管结局之间的关系。
Background: The objective of the current study is to evaluate the relationship between hostility and ambulatory cardiovascular activity in women with and without posttraumatic stress disorder (PTSD).Methods: One hundred and one women completed 24 hours of ambulatory monitoring and standardized diagnostic and hostility measures. Generalized estimating equations analysis was used to examine the effects of group and hostility factor scores (hostile beliefs, overt hostility, and covert hostility) on ambulatory heart rate (AHR) and ambulatory systolic (ASBP) and diastolic (ADBP) blood pressure.Results: After controlling for covariates, there was an interaction between PTSD and both hostile beliefs and overt hostility for AHR. Increases in hostility were associated with greater increases in heart rate among women with PTSD relative to those without PTSD. There was a similar interaction between hostile beliefs and group for ADBP.Conclusions: Increased AHR and blood pressure have been linked to poor cardiovascular outcomes in nonpsychiatric populations. Individuals with PTSD display increased hostility, a construct that has also been linked to poorer cardiovascular outcomes. Increases in hostile beliefs were associated with a greater increase in ADBP among women with PTSD as compared with control subjects. These data suggest that PTSD might in part moderate the relationship between hostility and cardiovascular outcomes.