Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury.
Temporally-patterned deep brain stimulation in a mouse model of multiple traumatic brain injury.
复制标题
多发性脑外伤小鼠模型中的时间模式深部脑刺激。
DOI：
10.1016/j.bbr.2014.07.026
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发表时间：
2014
影响因子：
2.7
通讯作者：
Pfaff,DonaldW
中科院分区：
文献类型：
--
作者：
Tabansky,Inna;Quinkert,AmyWells;Rahman,Nadera;Muller,SalomonZev;Lofgren,Jesper;Rudling,Johan;Goodman,Alyssa;Wang,Yingping;Pfaff,DonaldW
We report that mice with closed-head multiple traumatic brain injury (TBI) show a decrease in the motoric aspects of generalized arousal, as measured by automated, quantitative behavioral assays. Further, we found that temporally-patterned deep brain stimulation (DBS) can increase generalized arousal and spontaneous motor activity in this mouse model of TBI. This arousal increase is input-pattern-dependent, as changing the temporal pattern of DBS can modulate its effect on motor activity. Finally, an extensive examination of mouse behavioral capacities, looking for deficits in this model of TBI, suggest that the strongest effects of TBI in this model are found in the initiation of any kind of movement.
