Hormone therapy and cognitive function: Is there a critical period for benefit?
Hormone therapy and cognitive function: Is there a critical period for benefit?
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DOI：
10.1016/j.neuroscience.2006.01.001
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发表时间：
2006-01-01
期刊：
影响因子：
3.3
通讯作者：
Maki, PM
中科院分区：
文献类型：
--
作者：
Maki, PM
绝大多数接受激素治疗的妇女在生命早期就开始治疗更年期症状。然而，妇女健康倡议记忆研究是迄今为止唯一一项关于激素治疗和痴呆症的随机临床试验，是在65岁及以上的妇女中进行的。该试验为激素治疗对老年痴呆症女性的不利影响提供了重要的见解。这些发现对早期开始使用激素治疗的典型使用者的普遍性尚不清楚。为了解决这一重要问题，本文综述了激素治疗和痴呆风险的观察性试验，激素治疗和认知功能的随机临床试验以及基础科学研究。这些研究提供了暗示性的，但不是决定性的证据，表明早期开始激素治疗可能会提供认知益处，特别是对言语记忆和其他大脑介导的功能。其他形式的激素治疗，其他认知领域，和周期性激素方案可能不符合这一“关键期假说”。“需要进一步的研究来测试这一假设的有效性和局限性。(C)2006年IBRO。由爱思唯尔有限公司出版。保留所有权利。
The large majority of women receiving hormone therapy initiate therapy early in life for the treatment of menopausal symptoms. However, the Women's Health Initiative Memory Study, the only randomized clinical trial to date on hormone therapy and dementia, was carried out in women age 65 and older. That trial provided important insights into the detrimental effects of hormone therapy on dementia in women initiating later in life. The generalizability of those findings to the typical hormone therapy user who initiates earlier in life is unknown. To address this important issue, this review focuses on observational trials of hormone therapy and dementia risk, randomized clinical trials of hormone therapy and cognitive function, and basic science studies. These lines of research provide suggestive, but not definitive, evidence that early initiation of hormone therapy may provide cognitive benefits, particularly to verbal memory and other hippocampally mediated functions. Other forms of hormone therapy, other cognitive domains, and cyclic hormone regimens may not conform to this "critical period hypothesis." Further research is needed to test the validity and limits of this hypothesis. (C) 2006 IBRO. Published by Elsevier Ltd. All rights reserved.