Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1-infected individuals
Serum HIV-1 RNA levels compared to soluble markers of immune activation to predict disease progression in HIV-1-infected individuals
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DOI：
10.1159/000023949
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发表时间：
1998-07-01
影响因子：
2.8
通讯作者：
Möst, J
中科院分区：
文献类型：
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作者：
Zangerle, R;Steinhuber, S;Möst, J
我们评估了HIV-1RNA水平与可溶性免疫激活标记物，即新喋呤、β(2)-微球蛋白和可溶性肿瘤坏死因子受体75(sTNFR-75)的比较价值，以预测一年期间CD4+T细胞数量的变化、艾滋病的发展和生存期(中位随访54个月)。研究人群由47人组成，用于分析CD4+T细胞的变化和存活率(20人死亡)，以及31人组成的亚组，他们的基线CD4+T细胞高于200×10(6)/1，用于艾滋病的发展(11人发展为艾滋病)。用定量聚合酶链式反应检测保存血清中的HIV-1RNA。研究开始时获得的CD4+T细胞计数与基线血清HIV-1RNA水平密切相关(r=-0.47)，与新喋呤(r=-0.41)和β(2)-微球蛋白(r=-0.29)的相关性较小。CD4+T细胞的百分比变化与HIV-1RNA水平相关(r=-0.32，p=0.03)，而新喋呤、β(2)-微球蛋白和sTNFR-75的相关性更强(r=-0.51，r=-0.41，r=-0.32；p
We assessed the value of HIV-1 RNA level compared to soluble immune activation markers, namely neopterin, beta(2)-microglobulin and soluble TNF receptor 75 (sTNFR-75), to predict the change in the number of CD4+ T cells over a 1-year period, the development of AIDS, and survival (median follow-up 54 months). The study population comprised a cohort of 47 individuals for the analysis of the change in CD4+ T cells and survival (20 died), and a subgroup of 31 individuals with a baseline CD4+ T cells above 200 x 10(6)/1 for the development of AIDS (11 developed AIDS). HIV-1 RNA was measured from stored sera by quantitative PCR. The CD4+ T cell count obtained at study entry strongly con elated with baseline serum HIV-1 RNA levels (r = -0.47), and to a lesser extent with neopterin (r = -0.41) and beta(2)-microglobulin (r = -0.29). The percentage change in CD4+ T cells over a 1-year period correlated with HIV-1 RNA levels (r = -0.32, p = 0.03), however, stronger correlations were found for neopterin, beta(2)-microglobulin and sTNFR-75 (r = -0.51, r = -0.41, r = -0.32; p