TLR signaling and DNA repair: are they associated?
TLR signaling and DNA repair: are they associated?
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DOI：
10.1038/jid.2012.288
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Gaspari AA
中科院分区：
文献类型：
--
作者：
Harberts E;Gaspari AA
Toll样受体（TLR）信号转导是一种特异性的先天性免疫细胞防御机制，用于检测和应答病原体相关分子模式（PAMPs）。TLR信号传导是高度保守的，并且已经进化为具有识别来自广泛的微生物病原体的PAMP的细胞外和内体受体。最近的文献已经显示TLR的激活不仅导致细胞防御机制的上调，而且还导致DNA修复基因的上调和功能性DNA修复的增加。内体TLR激动剂导致电离和紫外线（UV）辐射后的存活和修复增加，表明单链和双链断裂的修复途径受到影响。这篇综述汇集了这些和其他实验结果，以研究DNA修复途径如何可能与TLR信号转导。还讨论了不同的结果和相关的生理意义，增加损伤后的DNA修复可能有。
Toll-like receptor (TLR) signaling is a well characterized, innate immue cellular defense mechanism used to detect and respond to pathogen-associated molecular patterns (PAMPs). TLR signaling is highly conserved and has evolved to have both extracellular and endosomal receptors that recognize PAMPs from a wide range of microbial pathogens. Recent literature has emerged to show that activation of TLRs not only leads to the upregulation of cellular defense mechanisms, but also results in upregulation of DNA repair genes and increased functional DNA repair. Endosomal TLR agonists result in increased survival and repair after both ionizing and ultraviolet (UV) radiation, suggesting that the repair pathways for single and double strand breaks are affected. This review brings together these and other experimental findings to examine how DNA repair pathways may be linked to TLR signaling. Also discussed are the varied outcomes and related physiological implications that increased DNA repair after injury might have.
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影响因子：
--
作者：
Edwards, L;Ferenczy, A;Schmitt, KA
通讯作者：
Schmitt, KA
DOI：
10.1038/nri2587
发表时间：
2009-08
期刊：
Nature reviews. Immunology
影响因子：
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作者：
通讯作者：
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影响因子：
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作者：
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通讯作者：
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