UreB immunodominant epitope‐specific CD8+ T‐cell responses were beneficial in reducing gastric symptoms in Helicobacter pylori‐infected individuals
UreB immunodominant epitope‐specific CD8+ T‐cell responses were beneficial in reducing gastric symptoms in Helicobacter pylori‐infected individuals
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DOI：
10.1111/hel.12959
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发表时间：
2023-02
期刊：
影响因子：
4.4
通讯作者：
T. He;Fang Zhang;J. Zhang;ShanShan Wei;J. Ning;Hanmei Yuan;Bin Li
中科院分区：
文献类型：
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作者：
T. He;Fang Zhang;J. Zhang;ShanShan Wei;J. Ning;Hanmei Yuan;Bin Li
虽然幽门螺杆菌被认为是一种细胞外感染细菌，但它可以导致感染后CD8+ T细胞数量的增加。目前，H.幽门螺杆菌抗原特异性CD 8 + T细胞和表位反应尚未阐明。本研究的重点是推定的保护性抗原UreB，以检测体外特异性CD8+ T细胞应答并筛选主要应答表位。
Although Helicobacter pylori is recognized as an extracellular infection bacterium, it can lead to an increase in the number of CD8+ T cells after infection. At present, the characteristics of H. pylori antigen‐specific CD8+ T cells and the epitope response have not been elucidated. This study was focused on putative protective antigen UreB to detect specific CD8+ T‐cell responses in vitro and screen for predominant response epitopes.