Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state
Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state
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DOI：
10.1007/s12026-013-8439-2
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发表时间：
2013-12-01
影响因子：
4.4
通讯作者：
Adkins, Becky
中科院分区：
文献类型：
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作者：
Adkins, Becky
新生动物对传染源的易感性更高，并且患哮喘等过敏性疾病的风险也更高。使用动物模型的实验研究对于开始识别这些敏感性背后的细胞和分子机制非常有用。特别是，小鼠新生儿模型的结果表明，多种免疫细胞类型的发育调节导致新生儿对病原微生物的反应通常较差。然而，令人惊讶的是，动物研究还表明，生命早期粘膜表面的反应可能有助于预防原发性或继发性疾病。我们对这些过程背后的分子事件的理解还不够深入。新的证据表明，新生儿免疫细胞的功能特性以及随后个体发育中免疫系统的成熟可能受到表观遗传现象的调节。在这里，我们回顾了我们小组和其他人的最新研究结果，描述了新生儿对感染的细胞反应和发育调节的表观遗传过程。
Neonatal animals have heightened susceptibility to infectious agents and are at increased risk for the development of allergic diseases, such as asthma. Experimental studies using animal models have been quite useful for beginning to identify the cellular and molecular mechanisms underlying these sensitivities. In particular, results from murine neonatal models indicate that developmental regulation of multiple immune cell types contributes to the typically poor responses of neonates to pathogenic microorganisms. Surprisingly, however, animal studies have also revealed that responses at mucosal surfaces in early life may be protective against primary or secondary disease. Our understanding of the molecular events underlying these processes is less well developed. Emerging evidence indicates that the functional properties of neonatal immune cells and the subsequent maturation of the immune system in ontogeny may be regulated by epigenetic phenomena. Here, we review recent findings from our group and others describing cellular responses to infection and developmentally regulated epigenetic processes in the newborn.