Neural-hunnoral responses during head-up tilt in healthy young white and black women
Neural-hunnoral responses during head-up tilt in healthy young white and black women
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DOI：
10.3389/fphys.2014.00086
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发表时间：
2014-03-04
影响因子：
4
通讯作者：
Fu, Qi
中科院分区：
文献类型：
--
作者：
Jarvis, Sara S.;Shibata, Shigeki;Fu, Qi
与白色妇女相比，年轻黑人妇女在怀孕期间有更高的高血压患病率，这可能归因于血压（BP）调节的差异。我们假设血压正常的年轻黑人女性会表现出增强的肌肉交感神经活动（MSNA）和肾-肾上腺反应的体位。15名白色和10名黑人女性（30 +/- 4 vs. 32 +/- 6岁;平均值SD）在基线（BL）、30和60度头高位倾斜（HUT）和恢复期测量了血流动力学和MSNA。抽血检测儿茶酚胺、直接肾素、血管加压素和醛固酮。白色女性的BL肱动脉收缩压（SBP：107 +/- 6 vs. 101 +/- 9 mmHg）和舒张压（DBP：62 +/- 4 vs. 56 +/- 7 mmHg）更高（均p < 0.05）。黑人女性的ADBP（60度HUT-BL）高于白色女性（p < 0.05）。两组的心输出量和总外周阻力相似。白人的MSNA爆发频率较高（BL：16 +/- 10 vs. 14 +/- 9爆发/min，主要效应p < 0.05），HUT期间两组的MSNA爆发频率均增加（60度：39 +/- 8 vs. 34 +/- 13爆发/min，BL的p < 0.05）。在60度HUT期间，白色女性的去甲肾上腺素较高（60度HUT 364 +/- 102 vs. 267 +/- 89 pg/ml，p < 0.05）。黑人的直接肾素较高，血管加压素和醛固酮倾向于较高（BL，直接肾素：12.1 +/- 5.0 vs. 14.4 +/- 3.7 pg/ml，p < 0.05; BL，加压素：0.4 +/- 0.0 vs. 1.6 +/- 3.6 pg/ml，p = 0.065; A醛固酮：-0.9 +/- 5.1 vs. 3.8 +/- 7.5 ng/ml; p = 0.069）。这些结果表明，年轻的血压正常的白色妇女可能更依赖于交感神经活动比黑人妇女谁有一种倾向，依靠肾肾上腺系统来调节血压在直立性应激。
Young black women have higher prevalence of hypertension during pregnancy compared to white women, which may be attributable to differences in blood pressure (BP) regulation. We hypothesized that young normotensive black women would demonstrate augmented muscle sympathetic nerve activity (MSNA) and renal-adrenal responses to orthostasis. Fifteen white and ten black women (30 +/- 4 vs. 32 +/- 6 years; means SD) had haemodynamics and MSNA measured during baseline (BL), 30 and 60 degrees head-up tilt (HUT), and recovery. Blood was drawn for catecholamines, direct renin, vasopressin, and aldosterone. BL brachial systolic BP (SBP: 107 +/- 6 vs. 101 +/- 9 mmHg) and diastolic BP (DBP: 62 +/- 4 vs. 56 +/- 7 mmHg) were higher in white women (both p < 0.05). ADBP (60 degrees HUT-BL) was greater in black women compared to white (p < 0.05). Cardiac output and total peripheral resistance were similar between groups. MSNA burst frequency was higher in whites (BL: 16 +/- 10 vs. 14 +/- 9 bursts/min, main effect p < 0.05) and increased in both groups during HUT (60 degrees : 39 +/- 8 vs. 34 +/- 13 bursts/min, p < 0.05 from BL). Noradrenaline was higher in white women during 60 degrees HUT (60 degrees HUT 364 +/- 102 vs. 267 +/- 89 pg/ml, p < 0.05). Direct renin was higher and vasopressin and Aaldosterone tended to be higher in blacks (BL, direct renin: 12.1 +/- 5.0 vs. 14.4 +/- 3.7 pg/ml, p < 0.05; BL, vasopressin: 0.4 +/- 0.0 vs. 1.6 +/- 3.6 pg/ml, p = 0.065; Aaldosterone: -0.9 +/- 5.1 vs. 3.8 +/- 7.5 ng/ml; p = 0.069). These results suggest that young normotensive white women may rely on sympathetic neural activity more so than black women who have a tendency to rely on the renal-adrenal system to regulate BP during an orthostatic stress.