Case-control study of bladder cancer and exposure to arsenic in Argentina
Case-control study of bladder cancer and exposure to arsenic in Argentina
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DOI：
10.1093/aje/kwh054
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发表时间：
2004-02-15
影响因子：
5
通讯作者：
Smith, AH
中科院分区：
文献类型：
--
作者：
Bates, MN;Rey, OA;Smith, AH
研究发现，饮用水中砷含量高会增加患膀胱癌的风险，但关于低浓度砷的风险信息很少。阿根廷的生态研究发现，在科尔多瓦省，膀胱癌死亡率增加，那里的一些水井受到中等浓度的砷污染。这项以人群为基础的膀胱癌病例对照研究在两个科尔多瓦县进行，在1996-2000年间招募了114对病例对照，年龄、性别和县相匹配。水样，特别是来自水井的水样，是从受试者目前的住所和过去40年的住所获得的。统计分析显示，没有证据表明与基于饮用水中砷浓度的暴露估计有关。然而，当井水消耗量本身作为暴露衡量标准时，时间窗口分析表明，在采访前50年以上使用井水与膀胱癌风险增加有关。这种关联仅限于吸烟者(访问前51-70年的优势比=2.5，95%可信区间：1.1，5.5)，不能排除这种关联是由于偶然的可能性。这项研究表明，砷导致膀胱癌的风险比其他研究预测的要低，但进一步证明，砷诱导的膀胱癌的潜伏期可能比之前认为的更长。
Studies have found increased bladder cancer risks associated with high levels of arsenic in drinking water, but little information exists about risks at lower concentrations. Ecologic studies in Argentina have found increased bladder cancer mortality in Cordoba Province, where some wells are contaminated with moderate arsenic concentrations. This population-based bladder cancer case-control study in two Cordoba counties recruited 114 case-control pairs, matched on age, sex, and county, during 1996-2000. Water samples, particularly from wells, were obtained from subjects' current residences and residences in the last 40 years. Statistical analyses showed no evidence of associations with exposure estimates based on arsenic concentrations in drinking water. However, when well-water consumption per se was used as the exposure measure, time-window analyses suggested that use of well water more than 50 years before interview was associated with increased bladder cancer risk. This association was limited to ever smokers (odds ratio = 2.5, 95% confidence interval: 1.1, 5.5 for 51-70 years before interview), and the possibility that this association is due to chance cannot be excluded. This study suggests lower bladder cancer risks for arsenic than predicted from other studies but adds to evidence that the latency for arsenic-induced bladder cancers may be longer than previously thought.