Familial support following childhood sexual abuse is associated with longer telomere length in adult females.
Familial support following childhood sexual abuse is associated with longer telomere length in adult females.
复制标题
童年性虐待后的家庭支持与成年女性较长的端粒长度有关。
DOI：
10.1007/s10865-019-00014-7
复制
发表时间：
2019
影响因子：
3.1
通讯作者：
Winter,MarciaA
中科院分区：
文献类型：
--
作者：
Sosnowski,DavidW;Kliewer,Wendy;York,TimothyP;Amstadter,AnandaB;Jackson-Cook,ColleenK;Winter,MarciaA
不良童年经历和端粒长度缩短之间存在明显的关联，但很少有研究研究可能缓和这种关联的因素，特别是与弹性框架的关联。本研究调查了儿童期性虐待(和虐待严重程度)与平均端粒长度之间的关系，以及社会支持和乐观情绪是否缓和了这种联系。样本包括99对白人单卵女性双胞胎，年龄从35岁到70岁(MAGE= 52.74，SD= 8.55岁)，她们为端粒分析提供了血液样本，以及关于她们儿童期性虐待史、特征乐观和当前社会支持的数据。线性混合效应模型被用来检验研究假设。在对全部样本的分析中，暴露于虐待或虐待严重程度对平均端粒长度没有影响，也没有乐观的主要或缓和效应。然而，在只包括遭受虐待的女性的分析中，存在虐待类型 × 支持互动：在经历过性交以外的其他形式虐待的女性中，较高的社会支持水平与较长的平均端粒长度相关。目前的研究结果阐明了儿童期性虐待在端粒磨损中的作用，并确定了一个可能防止儿童期性虐待的负面生物学影响的因素。
Robust associations between adverse childhood experiences and shortened telomere length exist, but few studies have examined factors that may moderate this association, particularly with a resilience framework. The present study examined the association between exposure to childhood sexual abuse (and abuse severity) and mean telomere length, and whether social support and optimism moderated this association. The sample included 99 White monozygotic female twins, ranging in age from 35 to 70 (Mage= 52.74,SD= 8.55 years), who provided a blood sample for telomere assay, and data on their childhood sexual abuse history, trait optimism, and current social support. Linear mixed effects models were employed to test study hypotheses. There were no effects of exposure to abuse or abuse severity on mean telomere length, nor were there main or moderating effects of optimism, in analyses of the full sample. However, in analyses that only included women exposed to abuse, there was an abuse type × support interaction: among women who experienced abuse in forms other than intercourse, higher levels of social support were associated with longer mean telomere length. Findings from the current study clarify the role of childhood sexual abuse in telomere attrition, and identify one factor that may protect against the negative biological effects of childhood sexual abuse.