Erectile Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Outcomes from a Multi-Center Study and Risk Factor Analysis in a Single Center.
Erectile Dysfunction in Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Outcomes from a Multi-Center Study and Risk Factor Analysis in a Single Center.
复制标题
慢性前列腺炎/慢性盆腔疼痛综合征引起的勃起功能障碍：多中心研究结果和单中心危险因素分析
DOI：
10.1371/journal.pone.0153054
复制
发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Deng C
中科院分区：
文献类型：
--
作者：
Zhang Y;Zheng T;Tu X;Chen X;Wang Z;Chen S;Yang Q;Wan Z;Han D;Xiao H;Sun X;Deng C
本研究旨在调查慢性前列腺炎/慢性盆腔疼痛综合征（CP/CPPS）患者勃起功能障碍（艾德）的患病率，探讨UPOINT领域、美国国立卫生研究院CP症状指数（NIH-CPSI）等因素对艾德患病率的影响。这是一项对2014年1月至7月期间在11家三级医院就诊的连续CP/CPPS患者进行的前瞻性研究。艾德被诊断为国际勃起功能指数（IIEF-5）评分<21分。采用UPOINT系统和NIH-CPSI对来自一个中心的患者进行评价。使用临床检查、社会人口学问卷、患者健康问卷（PHQ）、疼痛灾难性量表（PCS）、NIH-CPSI和IIEF-5对每位患者进行评估。11个中心的1406例患者（平均年龄32.18岁;范围18-60岁）入组。艾德见于638/1406例患者（45.4%），其中轻度291例（45.6%），中度297例（46.6%），重度50例（7.7%）。来自一家中心的192例患者平均年龄31.3岁; IIEF-5评分与NIH-CPSI呈负相关（r = 0.251），PHQ（r = 0.355）和PCS（r = 0.322）评分PHQ评分与NIH-CPSI呈正相关（P<0.001）NIH-CPSI、PHQ、PCS和IIEF-5评分在IIIA级和IIIB级CP/CPPS之间差异无统计学意义（P> 0.05）。多因素Logistic回归分析显示，UPOINT心理（P）领域和NIH-CPSI症状严重程度是CP/CPPS患者发生艾德的独立危险因素。提示心理因素和症状严重程度是CP/CPPS患者艾德发生的独立危险因素。
The aim of this study was to investigate the prevalence of erectile dysfunction (ED) in patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and explore the influence of UPOINT domains, National Institutes of Health-CP symptom index (NIH-CPSI) and other factors on ED prevalence. This was a prospective study of consecutive patients with CP/CPPS seen at 11 tertiary hospitals during January–July 2014. ED was diagnosed as a score of<21 on the International Index of Erectile Function (IIEF-5). Patients from one center were evaluated by the UPOINT system and NIH-CPSI. Each patient was assessed using clinical examination, asocio-demographic questionnaire, the Patient Health Questionnaire (PHQ), the Pain Catastrophizing Scale (PCS), NIH-CPSI and IIEF-5.1406 patients from 11 centers (mean age, 32.18 years; range 18–60 years) were enrolled. ED was found in 638/1406 patients (45.4%), and was categorized as mild in 291(45.6%), moderate in 297(46.6%) and severe in50(7.7%). 192 patients from one center(mean age,31.3 years; range 18–57 years) were further studied.IIEF-5 score correlated negatively with NIH-CPSI(r = 0.251), PHQ (r = 0.355) and PCS (r = 0.322)scores (P<0.001).PHQ score correlated positively with NIH-CPSI (r = 0.586) and PCS(r = 0.662) scores (P<0.001).NIH-CPSI, PHQ, PCS and IIEF-5 scores did not differ significantly between class IIIA and IIIB CP/CPPS. Multivariate logistic regression showed that UPOINT psychological (P) domain and NIH-CPSI symptom severity were independent risk factors for ED in CP/CPPS. It is concluded that psychological factors and symptom severity are independent risk factors for ED in CP/CPPS.