Regulation of blood volume during training in post-menopausal women.
Regulation of blood volume during training in post-menopausal women.
复制标题
绝经后妇女训练期间的血容量调节。
DOI：
10.1097/00005768-199801000-00013
复制
发表时间：
1998
影响因子：
4.1
通讯作者：
Nadel,ER
中科院分区：
文献类型：
--
作者：
Stachenfeld,NS;Mack,GW;DiPietro,L;Morocco,TS;Jozsi,AC;Nadel,ER
PurposeTo test the hypothesis that improvement in peak oxygen consumption（VO2peak）during training in older women is associated with specific central adaptations，such as BV expansion and a reduction in CPBR control of vascular tone.Methods17 healthy older women were randomized into training（N= 9，71+/-2 yr）and control（N= 8，73+/-3 yr）groups.训练组每周运动3 ~ 4次，以60%峰值心率运动30 min，共12 wk，然后以75%峰值心率运动40-50 min，共12 wk。对照组在同一时间段内参加瑜伽练习。我们测量了静息BV（伊文思蓝染料），VO 2峰值，和前臂血管阻力反应卸载低压机械感受器在低水平的下体负压（通过-20毫米汞柱）之前和之后的有氧训练。中心静脉压（刺激）每单位下降的前臂血管阻力（反应）的增加的斜率被用来评估CPBR responsibility. Results有氧训练增加VO 2峰值14.2%，从24.2 mL × kg（-1）× min（-1）至27.7 mL × kg（-1）× min（-1）（P< 0.05），一个较小的改善比通常在年轻的受试者。血容量（59.9+/-1.9和60.9+/-1.9 mL x kg [-1]）和CPBR功能（-3.98+/-0.92和-3.46 +/-0.94 units x mm（-1）Hg）在训练前后相似。此外，缺乏这些具体的适应可能有助于在较短的训练期间（10-12周）的老年妇女的VO 2峰值相对较差的改善。
PurposeTo test the hypothesis that improvement in peak oxygen consumption (VO2peak) during training in older women is associated with specific central adaptations, such as BV expansion and a reduction in CPBR control of vascular tone.MethodsSeventeen healthy older women were randomized into training (N= 9, 71+/-2 yr) and control (N= 8, 73+/-3 yr) groups. The training group exercised three to four times per wk for 30 min at 60% peak heart rate for 12 wk and then 40-50 min at 75% peak heart rate for 12 wk. The control group participated in yoga exercises over the same time period. We measured resting BV (Evans blue dye), VO2peak, and the forearm vascular resistance response to unloading low pressure mechanoreceptors during low levels of lower body negative pressure (through-20 mm Hg) before and after aerobic training. The slope of the increase in forearm vascular resistance (response) per unit decrease in central venous pressure (stimulus) was used to assess CPBR responsiveness.ResultsAerobic training increased VO2peak 14.2% from 24.2 mL x kg (-1) x min (-1) to 27.7 mL x kg (-1) x min (-1)(P< 0.05), a smaller improvement than typically seen in younger subjects. Blood volume (59.9+/-1.9 and 60.9+/-1.9 mL x kg [-1]) and CPBR function (-3.98+/-0.92 and-3.46+/-0.94 units x mm (-1) Hg) were similar before and after training.ConclusionsThese data indicate that the inability to induce adaptations in CPBR function may limit BV expansion during training in older women. In addition, the absence of these specific adaptations may contribute to the relatively poor improvements in VO2peak in older women during short (10-12 wk) periods of training.