Flow-independent angiography for peripheral vascular disease: Initial in-vivo results
Flow-independent angiography for peripheral vascular disease: Initial in-vivo results
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DOI：
10.1002/jmri.1880070405
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发表时间：
1997-07-01
期刊：
影响因子：
--
通讯作者：
Wright, GA
中科院分区：
文献类型：
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作者：
Gronas, R;Kalman, PG;Wright, GA
血流独立血管造影（FIA）是一种利用MR松弛特性而不是现在效应分离动脉血液的方法，评估了其在外周血管疾病（PVD）中的应用。首先，进行了初步研究，从对照组和有症状的PVD患者获得FIA冠状投影图像以评估临床效用，所有对照图像都符合预期的腿部动脉解剖结构，几乎没有深静脉（5个中的1个）和肌肉（5个中的0个）的干扰。与深静脉相比，浅静脉信号被抑制得较差（5个中的4个）。随后，我们比较了对照组（n = 8）和伴有间歇性跛行（n = 5）或缺血性静息痛（n = 7）的有症状患者的肌肉（T2(m)、胫骨前肌）、动脉血（股动脉和腘动脉）和静脉血（股、腘静脉和隐静脉）的T2值。各组织T2测量值的变化在有症状的患者中造成了较差的对比，缺血性休息痛患者的T2(m)明显高于对照组(T2(m) = 39.3 +/- 2.1（平均值的1个标准误差[SEM]），而30.9 +/- 0.4,P < 0.01)，除隐静脉外，所有测量值在有症状的患者中差异更大。为了实现FIA在临床应用中的固有优势，需要对肌肉、静脉和水肿信号的抑制进行额外的研究。一种有希望的方法是从投影图像转向三维采集，以改善组织抑制。
Flow-independent angiography (FIA), an approach that isolates arterial blood using MR relaxation characteristics rather than now effects, was evaluated for application in peripheral vascular disease (PVD). First, pilot studies were conducted in which FIA coronal projection images were obtained from controls and symptomatic patients with PVD to assess clinical utility, All control images corresponded to the expected leg arterial anatomy with little interference from deep veins (one of five) and muscle (zero of five). Superficial venous signal was less well suppressed in comparison to deep veins (four of five). Images of symptomatic patients were less consistent with difficulty suppressing muscle and deep venous signal in some cases and edema when present, We then compared T2 values for muscle (T2(m), tibialis anterior), arterial blood (femoral and popliteal arteries), and venous blood (femoral, popliteal, and saphenous veins) in controls (n = 8) and symptomatic patients with intermittent claudication (n = 5) or ischemic rest pain (n = 7). Changes in T2 measurements of various tissues accounted for poorer contrast in symptomatic patients, Patients with ischemic rest pain had significantly higher T2(m) compared with controls (T2(m) = 39.3 +/- 2.1 (1 standard error of the mean [SEM]) versus 30.9 +/- .4, P < .01), For all measurements, other than saphenous vein, variances were greater in symptomatic patients. To realize the inherent advantages of FIA for this clinical application, additional work on suppression of signals from muscle, veins, and edema is required, One promising approach involves shifting from projection images to three-dimensional acquisitions for improved tissue suppression.