Evidence of MAOA genotype involvement in spatial ability in males.
Evidence of MAOA genotype involvement in spatial ability in males.
复制标题
MAOA 基因型参与男性空间能力的证据。
DOI：
10.1016/j.bbr.2014.03.025
复制
发表时间：
2014
影响因子：
2.7
通讯作者：
Ernst,Monique
中科院分区：
文献类型：
--
作者：
Mueller,SvenC;Cornwell,BrianR;Grillon,Christian;Macintyre,Jessica;Gorodetsky,Elena;Goldman,David;Pine,DanielS;Ernst,Monique
Although the monoamine oxidase-A (MAOA) gene has been linked to spatial learning and memory in animal models, convincing evidence in humans is lacking. Performance on an ecologically-valid, virtual computer-based equivalent of the Morris Water Maze task was compared between 28 healthy males with the lowMAOAtranscriptional activity and 41 healthy age- and IQ-matched males with the highMAOAtranscriptional activity. The results revealed consistently better performance (reduced heading error, shorter path length, and reduced failed trials) for the highMAOAactivity individuals relative to the low activity individuals. By comparison, groups did not differ on pre-task variables or strategic measures such as first-move latency. The results provide novel evidence ofMAOAgene involvement in human spatial navigation using a virtual analogue of the Morris Water Maze task.
