APPARENT RELATIONSHIPS BETWEEN TOXINS ELABORATED BY THE CYANOBACTERIUM TRICHODESMIUM-ERYTHRAEUM AND THOSE PRESENT IN THE FLESH OF THE NARROW-BARRED SPANISH MACKEREL SCOMBEROMORUS-COMMERSONI
APPARENT RELATIONSHIPS BETWEEN TOXINS ELABORATED BY THE CYANOBACTERIUM TRICHODESMIUM-ERYTHRAEUM AND THOSE PRESENT IN THE FLESH OF THE NARROW-BARRED SPANISH MACKEREL SCOMBEROMORUS-COMMERSONI
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DOI：
10.1016/0041-0101(93)90131-2
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发表时间：
1993-09-01
期刊：
影响因子：
2.8
通讯作者：
LLEWELLYN, LE
中科院分区：
文献类型：
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作者：
ENDEAN, R;MONKS, SA;LLEWELLYN, LE
海洋蓝细菌Trichodesmium spirraeum含有有毒的水溶性物质，在小鼠中产生的症状与来自一批与类似雪卡毒素中毒有关的远洋鱼Scomberomorus spirussoni样本的肉的水溶性提取物所产生的症状相似。从蓝藻和鱼中提取的水溶性物质中含有色谱上无法区分的毒素。在部分纯化的水溶性材料提取物中检测到肽和生物碱。除该物质外，在某些批次的T. erythraeum.使用柱色谱法用9：1氯仿：甲醇洗脱该物质，产生的物质在色谱上与来自S.在小鼠中产生的迹象类似于由这种材料产生的迹象。用97：3氯仿：甲醇洗脱脂溶性物质，得到一种毒素，其色谱和毒性性质类似于S.你好其它毒素的Rf值介于类雪卡毒素和类箭毒毒素之间。erythraeum.推测T.黄姑鱼是某些鱼类携带的主要毒素的来源，黄姑鱼释放到周围海水中的水溶性毒素主要来自黄姑鱼。黄曲霉可能对人类健康构成危害。
The marine cyanobacterium Trichodesmium erythraeum contains toxic water-soluble material that produces signs in mice similar to those produced by water-soluble extracts of the flesh of a specimen of pelagic fish Scomberomorus commersoni from a batch that had been implicated in a poisoning resembling ciguatera. Extracts of water-soluble material from both the cyanobacterium and the fish contained toxins that were chromatographically indistinguishable. A peptide and an alkaloid were detected in partially purified extracts of the water-soluble material. In addition to this material toxic lipid-soluble material was present in some batches of T. erythraeum. Elution of this material with 9:1 chloroform:methanol using column chromatography produced material that was chromatographically indistinguishable from ciguatoxin-like material from S. commersoni and produced signs in mice similar to those produced by this material. Elution of the lipid-soluble material with 97:3 chloroform: methanol yielded a toxin resembling in its chromatographic and toxic properties a scaritoxin-like substance from S. commersoni. Other toxins with Rf values lying between that of the ciguatoxin-like material and that of the scaritoxin-like material were also detected in extracts of T. erythraeum. It is postulated that T. erythraeum is the progenitor of major toxins carried by some ciguateric fish and that water-soluble toxins released into the ambient sea water by T. erythraeum may constitute a health hazard for humans.